The important cereal crops of maize, rye, and wheat constitutively produce precursors to 2-benzoxazolinone, a phytochemical having antifungal effects towards many Fusarium species. However, verticillioides can tolerate 2-benzoxazolinone by converting it into non-toxic metabolites through the synergism two previously identified gene clusters, FDB1 FDB2 . Inspired induction these clusters upon ex...

INTRODUCTION Hepatobiliary elimination of endo- and xenobiotics is affected by different variables including hepatic perfusion, hepatocellular energy state and functional integrity of transporter proteins, all of which are altered during sepsis. A particular impairment of hepatocellular transport at the canalicular pole resulting in an accumulation of potentially hepatotoxic compounds would hav...

The placenta used to be regarded as an organ protecting the fetus from exposure to toxic chemicals. However, we now know that xenobiotics can cross through the placenta and enter the fetal blood stream (Barr et al., 2007). In addition, some toxicants may accumulate in the placenta and potentially affect its development or function. Therefore, understanding how the placenta affects xenobiotics, ...

Aquatic organisms are good bio-indicators of the environmental health in freshwater lakes; Xenobiotics are foreign materials to the organisms’ body and do not occur naturally in nature. Xenobiotics accumulate in adipose tissues due to high affinity to fatty tissues. This paper reports the levels of Organochlorine pesticide (OCPs) residues, their metabolites and Polychlorinated Biphenyl (PCBs) c...

We have been developing non-traditional methods of the identification of pollutants, using various hydrobionts as biological objects and the study of the mechanism of toxic action of xenobiotics. The experiments were carried out with using of Daphnia magna. Daphnia magna is a Crustacean in the order of Cladocera. Experiments were performed with a 2-days old culture of Daphnia magna. The toxicit...

Evolutionary processes have not yet developed specific and safe ways to detoxify all chemical species new to our environment. Indeed, some are transformed and/or conjugated by the liver into more toxic species. Environmental factors can modulate hepatic enzyme systems. Particularly responsive are the mixed function oxidases, which initiate the transformation of many xenobiotics to excretable sp...