نتایج جستجو برای: xl gene
تعداد نتایج: 1146384 فیلتر نتایج به سال:
and Applied Analysis 3 where Θ is a weight function, is called the scalar product of functions f, g on the interval 0, t . Let us recall that two functions are orthonormal when ∀i,j 〈 φi t , φj t 〉 δij , 2.2 where δij is the Kronecker delta. We are looking for an approximate solution to 1.1 as an element of the subspaceHnφ , spanned on nφ first basic functions {φj : j 1, 2, . . . , nφ} unφ x, t...
Translationally Controlled Tumor Protein (TCTP) is anti-apoptotic, key in development and cancer, however without the typical Bcl2 family members' structure. Here we report that TCTP contains a BH3-like domain and forms heterocomplexes with Bcl-xL. The crystal structure of a Bcl-xL deletion variant-TCTP11-31 complex reveals that TCTP refolds in a helical conformation upon binding the BH3-groove...
Extremely large-scale multiple-input-multiple-output (XL-MIMO) is promising to meet the high rate requirements for future 6G. To realize efficient precoding, accurate channel state information essential. Existing estimation algorithms with low pilot overhead heavily rely on sparsity in angular domain, which achieved by classical far-field planar-wavefront assumption. However, due non-negligible...
Abstract B-cell lymphoma X-large (BCL-XL) has been shown to promote breast cancer metastasis independently of its anti-apoptotic function. We recently found that proteolysis-targeting chimeras (PROTACs) against BCL-XL kill cells as well tumor-induced regulatory T (TI-Tregs). BCL-XL-targeting PROTACs can be potentially used treat metastatic – by direct killing circulating tumor at their vulnerab...
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unknown etiology affecting over 1% the US population. Deep epidermal infiltrative cysts and tunnels characteristic develop in intertriginous skin, with mixed immune infiltrate present inflamed regions, dominated by B T cells, but also including myeloid cells. Recent studies show progressive increase cells plasma as HS lesio...
Double-stranded decoy oligodeoxynucleotide (ODN) is a promising approach for inhibiting gene transcription. Signal transducer and activator of transcription (STAT) 3, a potent transcription factor, is usually constitutively activated in a variety of malignancies, and considered as an attractive drug target. In this study, it was noted that STAT3 was overactivated in human lung cancer cells, and...
OBJECTIVE High blood pressure is one of the most important risk factors, directly responsible for increasing the cardiovascular morbidity and mortality. The primary objective was to evaluate the efficacy of metoprolol XL/chlorthalidone against metoprolol XL/hydrochlorothiazide with respect to mean fall in systolic and diastolic blood pressure. The secondary objective was to compare the response...
Let (G, D) be a permutation representation of a finite group G acting on a finite set D. The cycle index of this representation is a polynomial P(G, D; Xl ,..., x,~) in several variables xl ,..., x~ with rational numbers as coefficients (see [1]). The restriction, made in [1], that the representation (G, D) is faithful, is unnecessary and we put no restriction on (G, D) whatsoever. We replace e...
A strain of the filamentous non N-fixing cyanobacterium Phormidium sp. isolated from Messolonghi (W. Greece) saltworks, was cultured in laboratory at six different combinations salinity (20-40-60 ppt) and illumination (low-2000 lux high-8000 lux). At salinities 60 40 ppt high (XL-8000 lux), growth rate (?max) presented highest values (0.491 0.401, respectively) compared to corresponding 20 (0.2...
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