Sun exposure has been clearly implicated in premature skin aging and neoplastic development. These features are exacerbated in patients with xeroderma pigmentosum (XP), a hereditary disease, the biochemical hallmark of which is a severe deficiency in the nucleotide excision repair of UV-induced DNA lesions. To develop an organotypic model of DNA repair deficiency, we have cultured several strai...

Let f be a C∞ function on R and P be a quadratic form defined by P (x) = P (x1, x2, · · · , xm) = x1+· · ·+xp−xp+1−· · ·−xp+q with p+q = m. In this paper, we mainly show that

While there are many claims for the successful use of extreme programming (XP) and agile modeling (AM), and the proponents can often be vocal in the extreme regarding their supposed benefits, research evidence supporting proponents‘ claims is somewhat lacking. Currently, the only research appearing to investigate the phenomena consists of two prominent streams. A small number of case studies an...

We have prospectively followed 16 Finnish xeroderma pigmentosum (XP) patients for up to 23 years. Seven patients were assigned by complementation analysis to the group XP-A, two patients to the XP-C group and one patient to the XP-G group. Six of the seven XP-A patients had the identical mutation (Arg228Ter) and the seventh patient had a different mutation (G283A). Further patients were assigne...

In recent years the Extreme Programming (XP) community has grown substantially. Many XP projects have started and a substantial amount are already finished. As the interest in the XP approach is constantly increasing worldwide throughout all software intensive application domains, it was time to start a first survey on XP. This paper presents the results of 45 evaluated questionnaires that have...

Although eXtreme Programming has been explained by Kent Beck[1], there are many benefits to adopting eXtreme Programming (XP) practices in other development processes. The benefits of adopting the complete XP approach are outside of the scope of this paper, what is discussed here are the lessons that XP offers to other development processes. This paper initially discusses the benefits available...

Sixty-one xeroderma pigmentosum (XP) patients living in the Federal Republic of Germany were investigated. Clinical symptoms were correlated with DNA repair parameters measured in fibroblasts grown from skin biopsies. Classification according to the international complementation groups revealed that of the 61 patients 3 belonged to group A, 26 to group C, 16 to group D, 3 to group E, and 2 to g...

Nucleotide Excision Repair (NER) is a pathway that removes lesions distorting the DNA helix. The molecular basis of the rare diseases Xeroderma pigmentosum (XP) and Cockayne Syndrome (CS) are explained based on the defects happening in 2 NER branches: Global-Genome Repair and Transcription-Coupled Repair, respectively. Nevertheless, both afflictions sporadically occur together, giving rise to X...

Software organizations are increasingly adopting the software development practices associated with the Extreme Programming (XP) methodology. Most reports on the efficacy of these practices are anecdotal. This paper provides a benchmark measurement framework for researchers and practitioners to assess concretely the extent to which an organization has adopted XP practices and the result of this...

Advitech is the developer of XP-828L. Abstract Background: XP-828L, a protein extract obtained from sweet whey, has demonstrated potential benefit for the treatment of mild to moderate psoriasis in an open-label study. Objective: To study in a randomized, double-blind, placebo-controlled study the safety and efficacy of XP-828L in the treatment of mild to moderate psoriasis. Design: XP-828L 5 g...