BACKGROUND Once-daily extended-release (XR) antiepileptic drugs (AEDs) offer potential adherence and tolerability advantages over their BID immediate-release (IR) counterparts. However, patients with epilepsy will inevitably be at least occasionally nonadherent with a prescribed dosing regimen, regardless of formulation. Although perturbations in plasma concentrations due to dosing irregulariti...

Resumen. Extreme Requirements (XR) es una propuesta que procura dar mayor calidad a la conducción de proyectos en Extreme Programming (XP), una de las metodologías más usadas dentro de las metodologías conocidas como ágiles cuyos elementos claves son: poca documentación, simplicidad, análisis como una actividad constante, diseño evolutivo, integraciones y testeo diarios. XR define una estrategi...

In this paper, we show a unified approach to the problem of characterizing general distribution functions based on the conditional expectation between adjacent order statistics, ξ(x) = E(h(Xr,n) | Xr+1,n = x) or ξ(x) = E(h(Xr+1,n) | Xr,n = x), where h is a real, continuous and strictly monotonic function. We have the explicit expression of the distribution function F from the above order mean f...

BACKGROUND AND OBJECTIVES The prevalence of ADHD is greater in substance use disorders than the general population, and ADHD and substance use disorders share neurobiological features such as dysregulation of reward circuitry. We tested the hypothesis that stimulants would decrease marijuana use in a randomized controlled trial of extended release mixed amphetamine salts (MAS-XR) for treatment ...

Mixed Amphetamine Salts Extended Release (MAS-XR or Adderall XR®) is a stimulant medication used to control symptoms of ADHD. People occasionally fail to take their medications. The goal of this pilot study was to assess the impact of a single missed medication on driving performance in 14 teen drivers with ADHD mixed type as a function of driving skill. A double-blind placebo control crossover...

PURPOSE To determine the cost effectiveness of duloxetine, a new serotonin norepinephrine reuptake inhibitor, when compared with venlafaxine-XR in treating major depressive disorder. METHODS A cost effectiveness analysis, using a decision tree modelled outpatient treatment over 6 months. Analytic perspectives were those of society (all direct and indirect costs) and the Ministry of Health of ...

Baker's yeast (Saccharomyces cerevisiae) has been genetically engineered to ferment the pentose sugar xylose present in lignocellulose biomass. One of the reactions controlling the rate of xylose utilization is catalyzed by xylose reductase (XR). In particular, the cofactor specificity of XR is not optimized with respect to the downstream pathway, and the reaction rate is insufficient for high ...

Let p be an odd prime and q = pm. Let l be an odd positive integer. Let p ≡ −1 (mod l) or p ≡ 1 (mod l) and l | m. By employing the integer sequence an = l−1 2 ∑ t=1 ( 2 cos π(2t− 1) l )n , which can be considered as a generalized Lucas sequence, we construct all the permutation binomials P (x) = xr + xu of the finite field Fq .

The XR-1 Chinese hamster ovary cell line is impaired in DNA double-strand break repair (DSBR) and in ability to support V(D)J recombination of transiently introduced substrates. We now show that XR-1 cells support recombination-activating gene 1- and 2-mediated initiation of V(D)J recombination within a chromosomally integrated substrate, but are highly impaired in ability to complete the proce...

• Four anti-epileptic drugs (AEDs) have been approved for the adjunctive treatment of primary generalized tonic-clonic seizures (PGTCS) in adults: topiramate [TPM], lamotrigine [LTG]/ lamotrigine-XR [LTG-XR], levetiracetam [LEV], and perampanel [PER]. • Five randomized-controlled trials were conducted to support these approvals [1-5]. Lamotrigine-XR applies to the US but not the EU. • These tri...