BACKGROUND Leukemia is characterized by the uncontrolled accumulation of white blood cells. Recently, cytokines have been used in immunotherapy, which is a new strategy for leukemia treatment. OBJECTIVE To investigate the effect of cytokines on induction of apoptosis in acute leukemic cell lines; HL-60, MV4-11, K-562 and Molt-4 and in addition, to study the involvement of nitric oxide (NO) in...

Bone marrow niche is the microenvironment where the leukemic cells residue and it support cell proliferation, metastasis, and drug resistance by secretion of numerous factors including cytokines. When leukemic cells grow, they disrupt normal hematopoietic progenitor cell (HPC) bone marrow niches and create abnormal microenvironments. Also, niches recently have been linked to the development of ...

conclusions to our knowledge, this is the first chronic case confirmed by the prolonged presence of hev rna in china. it is also the first reported persistent hepatitis e infection caused by hev genotype 4. case presentation here we report a chinese boy with acute lymphoblastic leukemia, who developed hepatitis e during a period of intensive chemotherapy. twenty months after the initial infecti...

background: for adult all patients, the indications and appropriate timing of allogeneic hematopoietic stem cell transplantation (ahsct) continue to be debated. the primary aim of this single-institution study was to compare the results of our adult all patients that had been allografted with those reported in the current literature. subjects and methods: this study included 53 consecutive adul...

Background: Scatter grams-graphic depictions of the cell populations in a blood sample are produced by automated analyzers. These scatter grams can be employed to screen for various hematological conditions, including anemia, leukemia, and other disorders examining gram’s population distribution patterning. Aims Objectives: In this study, we wish study generated Sysmex XN-series analyzer confir...

We analyzed rearrangements of the T cell receptor ‘y-chain (T7) gene as well as rearrangements of the T cell receptor /9-chain (Ta) gene and immunoglobulin heavy-chain (IgH) gene in 68 children with acute lymphoblastic leukemia (ALL). All 1 5 patients with T cell ALL showed rearrangements of both ‘F,, and T., genes. Twenty-four of 53 non-T, non-B ALL patients (45%) showed T7 gene rearrangements...

Background: Cancer is a public health emergency. It has a high mortality rate despite numerous studies on pharmaceutical therapies. Chimeric antigen receptor-natural killer (CAR-NK) cells are promising immunotherapy that could be used to treat cancer, especially leukemia. However, the evidence is still unclear. Thus, this systematic review aims to summarize the evidence regarding the use of CAR...

Citation: Sun Y, Beohou E, Labopin M, Volin L, Milpied N, Yakoub-Agha I, Piemontese D, Polge E, Houhou M, Huang XJ, Mohty M, Nagler A, and Gorin NC. Unmanipulated haploidentical versus matched unrelated donor allogeneic stem cell transplantation in adult patients with acute myelogenous leukemia in first remission: a retrospective pair-matched comparative study of the Beijing approach with the E...

Chimeric-antigen-receptor (CAR) T-cell therapy for CD19-expressing B-cell malignancies is already widely adopted in clinical practice. On the other hand, development of CAR-T-cell its nascent stage. One potential targets CD26, to which we have developed and evaluated efficacy safety humanized monoclonal antibody YS110. We generated second (CD28) third (CD28/4-1BB) generation CD26-targeted CAR-T...

Introduction: Oral Candidosis is among the find-ings of acute leukemia. The aim of this study was to evaluate the changes in the intensity of C.albicans, before treatment and at the Induc-tion phase.  Materials and Methods: Twelve patients with Acute Lymphoblastic Leukemia (ALL) aged 2-14 years enrolled in study. Whole Saliva samples were obtained and cultured to determine the mean count ...