We have created unique near-infrared (NIR)–emitting nanoscale metal-organic frameworks (nano-MOFs) incorporating a high density of Yb lanthanide cations and sensitizers derived from phenylene. We establish here that these nano-MOFs can be incorporated into living cells for NIR imaging. Specifically, we introduce bulk and nano-Yb-phenylenevinylenedicarboxylate-3 (nano-Yb-PVDC-3), a unique MOF ba...

The human Y box-binding protein-1 (YB-1) is a deoxyribonucleic acid (DNA)/ribonucleic acid (RNA)-binding protein with pleiotropic functions. Besides its roles in the regulation of transcription and translation, several recent studies indicate that YB-1 is a spliceosome-associated protein and is involved in alternative splicing, but the underlying mechanism has remained elusive. Here, we define ...

The thermoelectric properties, including electrical resistivity ~r!, Seebeck coefficient (S), and thermal conductivity ~k! on binary icosahedral Cd-Yb quasicrystals and Cd6Yb are investigated. The Cd-Yb quasicrystals have a room-temperature ~RT! resistivity value of about 200 ~mV cm!, however, the temperature-dependent resistivity is sensitive to a small composition change in these compounds. F...

Type-I collagen, the predominant component of extracellular matrix, is a triple-helical protein consisting of two alpha1 polypeptides and one alpha2 polypeptide. Expression of alpha1 and alpha2 procollagen genes is co-ordinately regulated under both normal and various pathological conditions. However, the basis of this co-ordinate regulation is not well known. YB-1b, a Y-box protein, has been s...

This study reports the effects of upconversion nanoparticles (UCNPs) LaF3:Yb,Er on zebrafish, with the aim of investigating UCNPs toxicity. LaF3:Yb,Er were prepared by an oleic acid/ionic liquid two-phase system, and characterized by transmission electron microscope and X-ray powder diffraction. 140 zebrafish embryos were divided into six test groups and one control group, and respectively were...

This manuscript reports on the interaction between (2)F5/2→(2)F7/2 radiative transition from Yb(3+) ions and localized surface plasmon resonance (from gold/silver nanoparticles) in a tungsten-tellurite glass. Such an interaction, similar to the down-conversion process, results in the Yb(3+) emission in the near-infrared region via resonant and non-resonant energy transfers. We associated such e...

The design of highly near-infrared (NIR) emissive lanthanide (Ln) complexes is challenging, owing to the lack of molecular systems with a high sensitization efficiency and the difficulty of achieving a large intrinsic quantum yield. Previous studies have reported success in optimizing individual factors and achieving high overall quantum yields, with the best yield being 12% for Yb(iii). Herein...

Altered miRNA expression is believed to play a crucial role in a variety of human cancers; however, the mechanisms leading to the dysregulation of miRNA expression remain elusive. In this study, we report that the human Y box-binding protein (YB-1), a major mRNA packaging protein, is a novel modulator of miRNA processing in glioblastoma multiforme (GBM). Using individual nucleotide-resolution c...

Tb-Yb co-doped NaYF4 nanoparticles (NPs) are prepared by sintering the assynthesized NaYF4:Tb, Yb NPs at 380°C under air atmosphere. The oxidization of Tb ions to Tb ions in NaYF4 NPs after sintering is demonstrated through X-ray photoelectron spectroscopy (XPS). The near-infrared (NIR) downconversion (DC) luminescence of TbYb couple is measured and investigated for the first time. The results ...

Resistance to chemotherapy is responsible for a failure of current treatment regimens in cancer patients. We have reported previously that the Y-box protein YB-1 regulates expression of the P-glycoprotein gene mdr1, which plays a major role in the development of a multidrug resistant-tumor phenotype. YB-1 predicts drug resistance and patient outcome in breast cancer. Thus, YB-1 is a promising t...