Previous studies have shown that aging is associated with alterations in muscle architecture and tendon properties (Morse CI, Thom JM, Birch KM, Narici MV. Acta Physiol Scand 183: 291-298, 2005; Narici MV, Maganaris CN, Reeves ND, Capodaglio P. J Appl Physiol 95: 2229-2234, 2003; Stenroth L, Peltonen J, Cronin NJ, Sipila S, Finni T. J Appl Physiol 113: 1537-1544, 2012). However, the possible in...

BACKGROUND Heart failure (HF) with normal ejection fraction (diastolic HF [DHF]) usually occurs in elderly patients with hypertension. The presence and significance of altered systolic and diastolic ventricular function in DHF is increasingly controversial. Our objective was to develop a clinically relevant large-animal model to better understand the pathophysiology of DHF. METHODS AND RESULT...

Visceral hypersensitivity is one of the most important mechanisms of functional gastrointestinal diseases. Our previous studies have shown that rapid eye movement (REM) sleep deprivation (REMSD) decreases visceral sensitivity in rats, but the mechanisms involved in this effect, have not yet been clarified. In this study, we investigated the role of the CNS and peripheral endocannabinoids in vis...

The bimolecular fluorescence complementation (BiFC) assay, which allows the investigation of interacting molecules in vivo, was applied to study complex formation between the splicing factor Y14 and nuclear export factor 1 (NXF1), which evidence indicates are functionally associated with nuclear mRNA. Y14 linked to the COOH terminus of yellow fluorescent protein (YFP; YC-Y14), and NXF1 fused to...

OBJECTIVE From 1995 to 2000, 422 youths, aged 18 years and under, died as a result of suicide in Quebec. More than one-third had received services from youth centres (YCs) at some point. This study sought to characterize a sample of those youths to improve services for this at-risk population. METHOD From a retrospective study of YCs and coroner's office files, we investigated the clinical fe...

One of the main indicators for the economical situation is the Yield Curve (YC). In particular, the most important part in the solution of the problem of the Asset liability management of a financial institution investing in bonds is the construction of the model of YC. There are many methods devoted to YC estimation, modelling and forecasting. YC is most often derived from all the bonds traded...

Swimming is considered one of the most conventional recreational activities for both leisure and exercising. Swimming pools have either public or private usage. Nevertheless, if the water of the swimming pools is polluted and is not identified on time, it could result in the transmission of various diseases to the people who use them. Therefore, the main objective of this study was to assess th...

The purpose of this study was to evaluate the characteristics carcass yields and internal external organs broilers fed diets containing fermented moringa leaf meal (FMOL) + yellow corn (YC), moringa-corn (MC) diet formulated replace parts commercial (CD). As many as 100 DOC broiler chicken strain CP 707 were reared for up 5 weeks feed experimental diets. A Block Randomized Design (BRD) with sub...

We tested the hypothesis that supplementation of nicotinamide mononucleotide (NMN), a key NAD(+) intermediate, increases arterial SIRT1 activity and reverses age-associated arterial dysfunction and oxidative stress. Old control mice (OC) had impaired carotid artery endothelium-dependent dilation (EDD) (60 ± 5% vs. 84 ± 2%), a measure of endothelial function, and nitric oxide (NO)-mediated EDD (...

BACKGROUND NF-Y is a transcription factor that recognizes with high specificity and affinity the widespread CCAAT box promoter element. It is formed by three subunits: NF-YA and the NF-YB/NF-YC- heterodimer containing histone fold domains (HFDs). We previously identified a large NF-Y gene family in Arabidopsis thaliana, composed of 29 members, and characterized their expression patterns in vari...