In the title one-dimensional coordination polymer, {[Eu(C(9)H(4)N(2)O(4))(C(9)H(5)N(2)O(4))(H(2)O)(3)]·2H(2)O}(n), one of the 1H-benzimidazole-5,6-dicarboxyl-ate (Hbdc) ligands is protonated at the imidazole group (H(2)bdc). The Eu(III) ion is eight-coordinated by two O atoms from two Hbdc ligands, three O atoms from two H(2)bdc ligands and three water mol-ecules, showing a distorted square-ant...

In the title complex, {[Cu(C(8)F(4)O(4))(C(4)H(8)O(2))(H(2)O)(2)]·2C(4)H(8)O(2)·2H(2)O}(n), the Cu(II) ion is six-coordinated by two oxygen donors from two trans 2,3,5,6-tetra-fluoro-1,4-dicarboxyl-ate (BDC-F(4)) ligands, two O atoms from two chair 1,4-dioxane ligands and two O atoms from two terminal water mol-ecules, adopting a distorted octa-hedral coordinated geometry. Each BDC-F(4) anion b...

Bile duct cannulation (BDC) studies are usually carried out in the rat to support the absorption, distribution, metabolism and excretion profiling of novel agrochemicals and pharmaceuticals. The different aspects of these studies (e.g. surgical preparation, dosing and collection of bile) can be intricate and/or technically complex. The animals are often kept singly housed for the duration of th...

1 Representation of horizontal head-on-body position in the primate superior 2 colliculus 3 4 5 Benjamin Nagy, Brian D. Corneil 6 7 CIHR Group in Action and Perception, 8 Graduate Program in Neuroscience 9 Departments of Physiology & Pharmacology and Psychology, 10 University of Western Ontario, 11 London, Ontario, Canada N6A 5C1 12 13 14 Running head: Head position gain fields in the superior ...

The study described here investigated the impact of intestinal excretion (IE; excretion of drug directly from circulation to intestinal lumen), enteroenteric recirculation (EER), and renal tubule recirculation (RTR) on apixaban pharmacokinetics and disposition. The experimental approaches involve integrating apixaban elimination pathways with pharmacokinetic profiles obtained from bile ductcann...

The study described here investigated the impact of intestinal excretion (IE; excretion of drug directly from circulation to intestinal lumen), enteroenteric recirculation (EER), and renal tubule recirculation (RTR) on apixaban pharmacokinetics and disposition. The experimental approaches involve integrating apixaban elimination pathways with pharmacokinetic profiles obtained from bile duct-can...

OBJECTIVE Type 1 diabetes is mediated by T-cell entry into pancreatic islets and destruction of insulin-producing beta-cells. The relative contribution of T-cells specific for different autoantigens is largely unknown because relatively few have been assessed in vivo. RESEARCH DESIGN AND METHODS We generated mice possessing a monoclonal population of T-cells expressing 1 of 17 T-cell receptor...

Biliary tract cancers carry dismal prognoses. It is commonly understood that chromosomal aberrations in cancer cells have prognostic and therapeutic implications. However, in biliary tract cancers the genetic changes have not yet been sufficiently studied. The aim of this study was to clarify the presence of mutations in specific chromosomal regions that are likely to harbor previously unknown ...

Hydrogen fuel is considered as a most promising alternative energy source for vehicles and portable electronics. For this technology to be practical for automobiles, the U.S. Department of Energy has established a design target of 6.0 wt% reversible hydrogen storage by 2010, but current materials fall far short of this goal. Consequently, many studies are devoted to metal hydride and carbon-bas...

Geometric spin frustration occurs when the structural arrangement of spins precludes the simultaneous satisfaction of all nearestneighbor interactions.1,2 The corner-sharing equilateral triangles of a kagomé lattice present an excellent construct on which to study spin frustration; spin liquid physics can result when the kagomé lattice features S ) /2 spins on lattice vertices.3-5 However, comp...