A 3-year-old boy with a history of four febrile convulsions since the age 1 year was admitted to hospital after experiencing cluster tonic seizures. Treatment started valproic acid (VPA), which proved be ineffective, so carbamazepine (CBZ) administered instead. This judged effective because seizures disappeared temporarily. The patient discharged, but he then had similar and consequently readmi...

SCN8A encodes Nav1.6, one of the main voltage-gated sodium channel subunits in the brain, and SCN8A mutations lead to epileptic encephalopathy. Particular mutations render the mutant channel more susceptible to inhibition by phenytoin. Yet, the potentially severe side effects of phenytoin maintenance therapy, especially cognitive impairment, are undesirable in these already cognitively impaired...

Recently, zonisamide (ZNS) has been approved as a new adjunctive therapy for motor complications of Parkinson's disease (PD). More recently, ZNS was reported to be effective for the management of impulse control behavior in PD, suggesting potential effects on non-motor PD symptoms. Dream enactment associated with aggressive, violent behavior can carry a serious risk of injury to patients, as we...

A simple, specific, accurate and precise Q-Absorbance ration spectrophotometric method was developed validated for estimation of Zonisamide Aripirazole in Synthetic Mixture. showed iso-absorptive point at 230.50nm Distilled water. The second wavelength used 240.60nm which is λmax distilled concentration the drugs determined by using ratio absorbance (λ1 =240.60 nm) (λ2 =230.50 nm). This linear ...