OBJECTIVE Human α1-acid glycoprotein has genetic variants, the F1, S, and A variants, which can be separated isoelectrophoretically. These variants show differences in their affinity of binding to several drugs. In this study, we investigated the factors determining drug binding to these α1-acid glycoprotein genetic variants using disopyramide, warfarin, and tamsulosin as marker compounds. ME...

The actions of catecholamines on adrenergic receptors (ARs) induce sympathetic responses, and sustained activation of the sympathetic nervous system results in disrupted circulatory homeostasis. In cardiomyocytes, α1-ARs localize to flask-shaped membrane microdomains known as "caveolae." Caveolae require both caveolin and cavin proteins for their biogenesis and function. However, the functional...

Nitric oxide (NO) receptor soluble guanylyl cyclase (sGC) is a key regulator of several important vascular functions and is important for maintaining cardiovascular homeostasis and vascular plasticity. Diminished sGC expression and function contributes to pathogenesis of several cardiovascular diseases. However, the processes that control sGC expression in vascular tissue remain poorly understo...

INTRODUCTION α1-Adrenoceptors are considered critical for the regulation of prostatic smooth muscle tone. However, previous studies suggested further α1-adrenoceptor functions besides contraction. Here, we investigated whether α1-adrenoceptors in the human prostate may activate extracellular signal-regulated kinases (ERK1/2). METHODS Prostate tissues from patients undergoing radical prostatec...

α1-antitrypsin deficiency is the most widely recognised genetic disorder causing chronic obstructive pulmonary disease (COPD). Mutant Z α1-antitrypsin expression has previously been linked to intracellular accumulation and polymerisation of this proteinase inhibitor. Subsequently, this has been described to underlie an exaggerated endoplasmic reticulum stress response and enhanced nuclear facto...

Assume X1,X2,…,XN are realizations of N observations from a real-valued discrete parameter third-order stationary process Xt,t=0±1,±2,…, with bispectrum fXXX(λ1,λ2) where “−π≤λ1,λ2≤π”. Based on the previous assumption, L different multitapered biperiodograms IXXX(mt)j(λ1,λ2);j=1,2,…,L overlapped segments (Xt(j);1≤t<N) can be constructed. Further, mean and variance average these expressed as ...

Let α1, α2, . . . , αn, β1, β2, . . . , βn be strictly positive reals with α1 +α2 + · · ·+αn = β1 + β2 + · · ·+ βn = s. In this paper, the inequality |||Aα1Bβ1Aα2 · · ·AαnBβn ||| ≤ |||AB|||s when A and B are positive-definite matrices is studied. Related questions are also studied.

Let a finite set N of points in a (finite-dimensional) normed space be given, and let α1, α2 be fixed nonnegative real numbers. The task is to find a connected graph G = (V,E) such that N ⊆ V and the cost C(G) = α1 · |V \N | + α2 · ∑