amyloid-β (aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in alzheimer’s disease pathology.uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

The circular dichroism spectra of native and recombined vinyl-(protojhematin horseradish peroxidase are identical, which confirms the proper position of the reintroduced group. The same observation and conclusion applies to the light absorption spectra. Circular dichroism and light absorption spectra of seven artificial peroxidases, prepared from apoperoxidase and 2,4substituted hematins, have ...

The effects of in vitro treatment of the hepatic microsomal fraction with various porphyrin compounds on the activity and the content of the heme-containing components of the mixed function oxidase system were studied. The compounds examined were hematin, methemalbumin (with heme to protein molar ratio of 13:1 or 1:1), mesohemalbumin, bilirubin, biliverdin, mesoporphyrin IX, and protoprophyrin ...

in this paper the synthesis of some new polyaromatic monocyclic β-lactams has been reported. these cycloadducts have been synthesized by the [2+2] ketene-imine cycloaddition reaction known as the staudinger reaction. all of the products have been fully characterized by ir, 1h-nmr, 13c-nmr, mass spectroscopy and elemental analyses. the x-ray crystal structure of a cis β-lactam has been also pres...

Amyloid formation in the pancreatic islets due to aggregation of human islet amyloid polypeptide (hIAPP) contributes to reduced β-cell mass and function in type 2 diabetes (T2D) and islet transplantation. Protein kinase B (PKB) signaling plays a key role in the regulation of β-cell survival, function and proliferation. In this study, we used human and hIAPP-expressing transgenic mouse islets in...