Yanofsky (1) originally proposed N-(5’-phosphoribosyl)anthranilic acid as the first intermediate after anthranilic acid in tryptophan biosynthesis in microorganisms. Evidence was subsequently found which suggested that this compound is formed enzymatically from anthranilic acid and ribosylpyrophosphate 5-phosphate (2, 3). Although the dephosphorylated form of PRA,’ N-ribosylanthranilic acid, ha...

Relationships among plasma renin activities (PRA), plasma angiotensin II (ATII) concentrations, atrial natriuretic peptide (ANP) concentrations and cardiopulmonary function values were examined in dogs with ascitic pulmonary heartworm disease and acute- and chronic-vena caval syndrome (CS). PRA, plasma ATII concentration and plasma ANP concentration tended to be higher or were significantly hig...

To characterize the renln-angiotensin system in the Aokl-Okamoto spontaneously hypertensive rat (SHR) more fully, serial measurements of plasma renin activity (PRA), plasma renin concentration (PRC), renin reactivity (as relative index of circulating modifiers of the renin reaction) and renin substrate concentration were made in 6to 64-week-old SHR and in age-matched Wistar-Kyoto normotensive r...

PURPOSE To determine the distribution of negative relative accommodation (NRA) and positive relative accommodation (PRA) and its relationship with binocular vision indices in a young population. METHODS In this cross-sectional study conducted in a student population, samples were selected through multistage cluster sampling. All the samples underwent the measurement of uncorrected and correct...

In 19 control subjects, 33 patients with essential hypertension and normal plasma renin activity (PRA) and 11 patients with low PRA, secretory rates of 18-hydroxy-11-deoxy-corticosterone (18-OH DOC), 11-deoxycorticosterone (DOC) and corticosterone were measured. Patients with low PRA were significantly older and had higher arterial pressure and slightly lower plasma potassium levels than patien...

PURPOSE Report on the anatomic qualification of the snuffbox radial artery (SBRA) and proximal radial artery (PRA) for pAVF.
 METHODS Retrospective analysis of upper extremity mapping in 64 limbs in 55 dialysis patients was performed. The radial artery was assessed for diameter, patency, flow and proximity to the adjacent vein to SBRA and PRA. Sites qualified for pAVF on a binary basis when t...

A 37-year old woman was suspected of having renovascular hypertension because of recent onset severe hypertension (blood pressure 220/135 mmHg; compared to 132/65 mmHg two years earlier) and an abdominal bruit. A captopril renal scan indicated the presence of right renal artery stenosis. Additionally, a captopril plasma renin activity (PRA) provocation test showed a positive result for renovasc...

To assess the interaction between adrenergic activity and blood pressure regulation in patients with chronic renal failure, plasma norepinephrine (NE) and plasma renin activity (PRA) were measured before and after vigorous ultrafiltration. The significance of PRA was further assessed by angiotensin blockade with saralasin. Two patterns of response were defined: nine patients had low levels of P...