Introduction: The impact of viral factors like genotype, HCVRNA at baseline, or viral kinetics during treatment of chronic hepatitis C patients is better defined recently. In contrary different results comes from studies about the impact of age, gender or BMI on treatment response in chronic hepatitis C (CHC) with standard scheme. Aim: To evaluate the predictive value of host factors (age, gend...

BACKGROUND & AIMS We performed a prospective study to investigate the effects of a sustained viral response (SVR) on outcomes of patients with hepatitis C virus (HCV) infection and compensated cirrhosis. METHODS We collected data from 1323 patients included in the prospective Agence Nationale pour la Recherche sur le SIDA et les hépatites virales (ANRS) viral cirrhosis (CirVir) cohort, recrui...

80 The Journal of Thoracic and Cardio n this issue, Menicanti and colleagues describe the experience with surgical ventricular restoration (SVR) procedures at the San Donato Hospital between 1989 and 2005. The study is important for a number of reasons. First, 300 patients underwent SVR. This is the largest single-center experience to ate, and the authors are to be commended for the excellent o...

AIM To investigate shear wave (SW) propagation velocity in patients with untreated hepatitis C and patients with sustained virological response (SVR). METHODS A total of 136 hepatitis C patients [85 patients who had not received antiviral therapy (naïve group) and 51 patients who had received antiviral therapy and subsequently achieved SVR of at least 24 wk (SVR group)] and 58 healthy volunte...

BACKGROUND The combination of sofosbuvir (SOF), ribavirin (RBV) and peg-interferon-alfa-2a (peg-IFN-alfa-2a) as well as the combination of SOF and RBV for the treatment of patients infected with hepatitis c virus (HCV) has improved rates of sustained virological response (SVR) considerably in recent trials. However, there is only limited data concerning the efficacy and safety in a "real-life" ...

Combination therapy with pegylated interferon and ribavirin is considered the new standard therapy for naïve patients with chronic hepatitis C. We evaluated the efficacy and safety of treatment with weight-based peginterferon alpha-2b (1.5 mg/kg per week) plus ribavirin (800-1,200 mg/day) for 48 weeks in naïve, relapser and non-responder (to previous treatment with interferon plus ribavirin) pa...

Modeling NOx emissions from coal fired utility boiler is critical to develop a predictive emissions monitoring system (PEMS) and to implement combustion optimization software package for low NOx combustion. This paper presents an efficient NOx emissions model based on support vector regression (SVR), and compares its performance with traditional modeling techniques, i.e., back propagation (BPNN...

The combination of pegylated interferon (PEG-INF) and ribavirin is currently the best treatment for chronic hepatitis C, providing a sustained virological response (SVR) in 54%-63% of patients. In patients infected with hepatitis C virus (HCV) genotype 1, the SVR rate is 42%-52%. To evaluate the treatment efficacy of this drug combination, we conducted an open, prospective study of 58 consecuti...

The ν-Support Vector Regression (ν-SVR) is an effective regression learning algorithm, which has the advantage of using a parameter ν on controlling the number of support vectors and adjusting the width of the tube automatically. However, compared to ν-Support Vector Classification (ν-SVC) (Schölkopf et al., 2000), ν-SVR introduces an additional linear term into its objective function. Thus, di...

BACKGROUND/AIMS Peginterferon plus ribavirin remains a standard therapy for patients with chronic hepatitis C (CHC) in Korea. We investigated the efficacy and long-term outcome of peginterferon and ribavirin therapy in Korean patients with CHC, particularly in relation to the stage of liver fibrosis. METHODS The incidence of sustained virological response (SVR), hepatic decompensation, hepato...