نتایج جستجو برای: بهترین شیوههای مدیریت bmp

تعداد نتایج: 98086  

2013
Kei Inai Jessica L. Burnside Stanley Hoffman Bryan P. Toole Yukiko Sugi

Distal outgrowth and maturation of mesenchymalized endocardial cushions are critical morphogenetic events during post-EMT atrioventricular (AV) valvuloseptal morphogenesis. We explored the role of BMP-2 in the regulation of valvulogenic extracellular matrix (ECM) components, versican and hyaluronan (HA), and cell migration during post-EMT AV cushion distal outgrowth/expansion. We observed inten...

2017
Jingdong Guo Quan Lin Ying Shao Li Rong Duo Zhang

Scarring is the inevitable consequence of wound repair, which may cause significant physical and mental pain to patients when excessive. Bone morphogenetic protein‑7 (BMP‑7) has been proved to inhibit TGF‑β‑induced fibrosis in various tissues including dermal papilla cells. However, the effect of BMP‑7 on hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, has not been...

2017
Jonathan Gill Patrick Connolly Michael Roth So Hak Chung Wendong Zhang Sajida Piperdi Bang Hoang Rui Yang Hillary Guzik Jonathan Morris Richard Gorlick David S Geller

PURPOSE Bone Morphogenetic Protein-2 (BMP-2) may offer the potential to enhance allograft-host osseous union in limb-salvage surgery following osteosarcoma resection. However, there is concern regarding the effect of locally applied BMP-2 on tumor recurrence and metastasis. The purpose of this project was to evaluate the effect of exogenous BMP-2 on osteosarcoma migration and invasion across a ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه مازندران - دانشکده ریاضی 1392

معیارهای متفاوتی ‎‎ برای مقایسه برآوردگرهای پارامتر‎های‎‎ مجهول‏ پیشنهاد شده است. معیار میانگین توان دوم خطا ‎ ‎(mse)‎ ‎‎‎ مهمترین معیار برای مقایسه برآوردگرهای مختلف می باشد. اما موقعیت هایی وجود دارند که ‎‎‎‎mse‎‎ وجود ندارد یا به دلایل مختلفی نمی توانیم آن را تعیین کنیم. به همین دلیل معیار نزدیکی پیتمن در سال 1937 توسط پیتمن به عنوان یک معیار مقایسه ای جایگزین برای ‎‎‎mse‎‎ پیشنهاد شده است. ...

2012
Ariadne Cristiane Cabral CRUZ Mariana Lúcia SILVA Thiago CAON Cláudia Maria Oliveira SIMÕES

UNLABELLED Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells. OBJECTIVES This study evaluated the effect of a recombinant BMP-2 as well as the endogenous BMP-4 and BMP-7 in the osteogenic differentiation of adipose-derived stem cells (ASCs) in medium supplemented with ascor...

Journal: :European cells & materials 2016
J Bolander W Ji L Geris V Bloemen Y C Chai J Schrooten F P Luyten

When combining osteogenic progenitor cells such as human periosteum derived cells (hPDCs) with osteoconductive biomaterials like calcium phosphate (CaP)-scaffolds, in vivo bone formation can be achieved. This process is dependent on the early activation of Bone morphogenetic protein (BMP)-signalling. However, the bone forming process is slow and routinely only a limited amount of bone and bone ...

Journal: :Mechanisms of Development 1998
Birgit Andrée Delphine Duprez Britta Vorbusch Hans-Henning Arnold Thomas Brand

In Drosophila induction of the homeobox gene tinman and subsequent heart formation are dependent on dpp signaling from overlying ectoderm. In order to define vertebrate heart-inducing signals we screened for dpp-homologues expressed in HH stage 4 chicken embryos. The majority of transcripts were found to be BMP-2 among several other members of the BMP family. From embryonic HH stage 4 onwards c...

2012
Shaila Ahmed Raghu Prasad Rao Metpally Sreedhara Sangadala Boojala Vijay B Reddy

Bone growth factors, such as Bone Morphogenic Protein-2 (BMP-2) have been approved by the FDA to replace grafting for some surgical interventions, but the high dose requirement limits its use in patients. Noggin, an extracellular protein, blocks the effect of BMP-2 by binding to BMP. Preventing the BMP-2/noggin interaction will help increase the free concentration of BMP-2 and therefore should ...

2016
Lisa Deignan Marco T. Pinheiro Catherine Sutcliffe Abbie Saunders Scott G. Wilcockson Leo A. H. Zeef Ian J. Donaldson Hilary L. Ashe

The BMP signaling pathway has a conserved role in dorsal-ventral axis patterning during embryonic development. In Drosophila, graded BMP signaling is transduced by the Mad transcription factor and opposed by the Brinker repressor. In this study, using the Drosophila embryo as a model, we combine RNA-seq with Mad and Brinker ChIP-seq to decipher the BMP-responsive transcriptional network underpi...

امامی پور, سوزان , شمس اسفندآباد, حسن , صدرالسادات, سید جلال ,

زمینه و هدف: در دو دهه اخیر، رابطه بین شیوههای فرزند پروری و کارکرد خانواده توسط پژوهشگران بسیاری مورد مطالعه قرار گرفته است. در پژوهش حاضر رابطه بین شیوههای فرزند پروری و کارکرد خانواده در خانواده‏های کودکان دارای اختلالات رفتاری، خانواده‏های کودکان بد سرپرست و خانواده‏های کودکان عادی مورد مقایسه قرار گرفت. روش بررسی: در یک مطالعه توصیفی - تحلیلی پرسشنامه های مشخصات فردی ـ اجتماعی، سنجش عملکر...

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