I. Overview of Analytical Issues for Heart Failure Biomarkers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e95 A. Background. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .e95 II. Analytical Biomarker Issues . . . . . . . . . . . . . . . . . . .e96 A. Issues Related to B-Type Natriuretic Peptide (BNP) and N-Terminal proB-Type Natriuretic Peptide (NTproBNP) Measure...

Among the most promising tests for early detection of congestive heart failure (CHF) are brain natriuretic peptides (BNPs), but it is unclear if homocysteine can aid in differentiating those with and without disease. We attempt to use a combination of tests to reduce the need for echocardiography without missing any cases of CHF. We compared 50 CHF patients with an ejection fraction of less tha...

BACKGROUND We hypothesized that plasma levels of brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) would be elevated, and adiponectin concentrations reduced, in patients with atherosclerotic renal artery stenosis (ARAS) and that BNPs might be used to identify patients who would benefit from percutaneous transluminal renal angioplasty (PTRA). METHODS Data were collected before...

OBJECTIVE To examine the diagnostic value of serum B-type natriuretic peptide (BNP) in acute Kawasaki disease (KD). DESIGN Systematic review and meta-analysis. DATA SOURCES A systematic literature search strategy was designed and carried out using MEDLINE, EMBASE and the Cochrane Library from inception to December 2013. We also performed manual screening of the bibliographies of primary stu...

Recent studies report that, in the absence of heart failure and renal failure, plasma B-type natriuretic peptide (BNP) has prognostic value for mortality. We sought to confirm and extend these previous studies to assess BNP, measured by 3 distinct assays, as a biomarker for mortality in a strategy to enhance efforts at primary prevention and to better understand the clinical phenotype of such s...

BACKGROUND Intravenous levosimendan is indicated for acute heart failure. The compound has shown promising beneficial effects in ischemic stroke models. OBJECTIVE We evaluated the efficacy and safety of oral levosimendan in patients with a history of cerebral ischemia. METHODS In a randomized, double-blind, placebo-controlled, parallel-group study, 16 patients with a history of ischemic str...

INTRODUCTION Preoperative functional capacity is considered an important risk factor for cardiovascular and other complications of major non-cardiac surgery. Nonetheless, the usual approach for estimating preoperative functional capacity, namely doctors' subjective assessment, may not accurately predict postoperative morbidity or mortality. 3 possible alternatives are cardiopulmonary exercise t...

BACKGROUND Previous studies have reported that natriuretic peptides in the blood and pleural fluid (PF) are effective diagnostic markers for heart failure (HF). These natriuretic peptides include N-terminal pro-brain natriuretic peptide (NT-proBNP), brain natriuretic peptide (BNP), and midregion pro-atrial natriuretic peptide (MR-proANP). This systematic review and meta-analysis evaluates the d...

Background: Developments in the information and digital technology sector have provided a solid foundation for emergence of smartphones. Heart failure is very important to monitor. Given this, remote monitoring strategy involves smartphones . Objective: get an overview applications or m-Health, which allows independent surveillance self-care heart patients. Method: The methodology this review f...