Ribosomes play a critical role in maintaining cellular proteostasis. The binding of messenger RNA (mRNA) to the ribosome regulates kinetics protein synthesis. To generate an understanding structural, mechanistic, and dynamical features mRNA recognition ribosome, we have analysed mRNA-protein interactions through structural comparison ribosomal complex presence absence mRNA. do so, compared 3-Di...

Background: There is no follicular development during pregnancy in the rat comparable to the changes of the estrous cycle. RFamide-related peptide-3 (RFRP-3) and kisspeptin were recognized as regulator of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in several species, including the rat. The aim of the present study was to evaluate the relative expression of RFRP...

Long non-coding RNAs (lncRNAs) play a multifaceted role in transcriptional regulation, and the potential molecular regulatory mechanisms of lncRNAs lncRNA–miRNA–mRNA networks body color formation are great significance for its selective breeding. Therefore, lncRNA-miRNA-mRNA ceRNA network red- black-colored Plectropomus leopardus were identified analyzed. Sequencing analyses 167 differentially ...

Emerging therapeutic treatments based on the production of proteins by delivering mRNA have become increasingly important in recent times. While lipid nanoparticles (LNPs) are approved vehicles for small interfering RNA delivery, there still challenges to use this formulation delivery. LNPs typically a mixture cationic lipid, distearoylphosphatidylcholine (DSPC), cholesterol, and PEG-lipid. The...

The scientific review considers the mechanisms of action cytoplasmic microRNAs, namely miRNA-mediated silencing, which is caused during initiation and post-initiation period translation. To write article, information was searched using Scopus, Web Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, Cochrane Library, CyberLeninka databases. It known that silencing translation occurs...

The COVID-19 pandemic has stimulated the production of different therapeutic approaches for resolution coronavirus infections. On one hand, nanobiomolecules have been proposed as bait material viruses,1,2 on other hand unconventional messenger RNA vaccines produced like SARS-CoV-2 mRNA (BioNTech/Pfizer BNT162b2 and Moderna mRNA-1273). [...]