Many of the drugs leave the market due to their adverse effects than their therapeutic effects. If the pharmacology of the drug and its adverse effect is Circadian Time (CT) dependent, it can be modulated by altering the time of administration of drugs. Chronopharmacology describes the effect of drugs in terms of time of administration. Its main objective is chronotherapy (time based treatment)...

Parkinson's disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments. The objectives were to support data on exercise benefits to PD. Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise. The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6...

Buscando o desenvolvimento regional de municípios do Meio Oeste Catarinense através da proposta uma rota turística com foco em vitivinicultura, este estudo tem como objetivo mapear os região que se enquadram dentro perfil para a rota. Durante pesquisa foi realizada coleta dados verificando legislação, diretrizes, infraestrutura básica e rotas existentes já beneficiam turismo. Foi possível concl...

Sir, I read with interest the paper by Cappuccio et al. on implementing an EWTD-compliant rota. Whilst the paper makes for interesting reading, I do not believe that the authors’ conclusions can be drawn from the data that they present. First, the sample size is too small to produce meaningful information. Second, the control (52 h) and intervention (48 h) groups were performed on two separate ...

This article aims to evaluate the possible antidepressant effect of Ghrita prepared from combination these plants and provide probable scientific explanations for using medicated (ghee) in Ayurvedic system medicine. Herbs like Marsilea quadrifolia, Lawsonia inermis, Mimosa pudica, Piper betle were collected freshly during month June. One part Kalka (herb bolus), 4 parts pure cow ghee, 16 Dravad...

abstract   background: pseudoarthrosis of the tibia poses one of the most challenging treatment problems in all of orthopedics. the goal of the study was to assess the clinical outcome of intramedullary rod fixation in its treatment.   methods: the results of the management for nine patients with pseudoarthrosis of the tibia with im rod fixation were reviewed retrospectively between 1986 - 2006...

Recently, the theory of renormalization in perturbative quantum field theory underwent some exciting new developments. Kreimer discovered an organization of Feynman graphs into combinatorial Hopf algebras. The process of renormalization is captured by a factorization theorem for regularized Hopf algebra characters. Hereby the notion of Rota–Baxter algebras enters the scene. In this note we revi...

The classical Spitzer and Bohnenblust–Spitzer identities [17, 1, 15] from probability theory can be formulated in terms of certain algebraic structures known as commutative Rota-Baxter algebras. Recently, Ebrahimi-Fard et al. [3] have extended these identities to noncommutative Rota-Baxter algebras. Their results can in fact be formulated in terms of dendriform dialgebras [4], a class of associ...