This study aimed to compare tear film viscosity (TFV) in Sjögren and non-Sjögren dry eye diseases (DEDs). was a cross-sectional observational study. A total of 68 DED patients were enrolled, including 32 with syndrome (SS) 36 without SS. TFV assessed by analyzer determined the momentary moving speed (MMS; MMS (t) = α × t−β, t time (s)) its power-law fitting-derived parameters (α β). Among four ...

Background: Post- Laser- assisted in situ keratomileusis (LASIK) dry eye is one of the most common postoperative eyes after ophthalmic surgeries. Clinically, patients have positive vital staining ocular surface, decreased tear breakup times, reduced corneal sensitivity, and visual acuity. In majority patients, symptoms last about month, but some can experience these for more than a year. Case p...

The typical as-built coarse and cube-oriented microstructure of Inconel® 625 parts fabricated via arc-based directed energy deposition (DED) induces anisotropic mechanical behavior, reducing the potential applications DEDed in critical components. In this sense, present work aimed to reduce grain size texture by applying an situ interlayer hot forging (HF) combined with post-deposition heat tre...

Powder bed fusion (PBF) is an additive manufacturing (AM) technique commonly used to manufacture metallic components. External geometry of parts printed by PBF process can be extended regular processes, namely, laser cladding and spraying powder metal. But these methods have disadvantages such as increased heat-affected zone (HAZ) deficiencies like cracks pores, whereas samples produced with di...

Background: Dry eye disease (DED) is a common and debilitating condition that affects millions of people worldwide. Despite its prevalence, the diagnosis management DED can be challenging, as multifactorial symptoms nonspecific. In recent years, there have been significant advancements in diagnostic technology for DED, including development several new devices. Methods: A literature review arti...

During Laser Powder-Directed Energy Deposition (LP-DED), many complex phenomena occur. These phenomena, which are strictly related to the conditions used during building process, can affect quality of parts in terms microstructural features and mechanical behavior. This paper investigates effect parameters on microstructure tensile properties AISI 316L stainless-steel samples produced via LP-DE...

The quality of metal components manufactured by laser-based additive manufacturing technologies is governed the process parameters. Moreover, parameters differ depending on material used. In particular, direct energy deposition (DED) technology vulnerable to control external environmental variables, and there are many such as powder characteristics laser parameters, thus tests required determin...

Purpose The purpose of this study was to evaluate the inhibitory mechanism of fingolimod and the involvement of sphingosine-1-phosphate receptors (S1PRs) and cytokines-matrix metalloproteinases (MMPs)/MAP kinases (MAPKs) signaling in a dry eye disease (DED) mouse model. Methods Sixty-four male NOD mice (DED model) and 16 age-matched BALB/c mice were used. In a preliminary experiment, 16 NOD m...

The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED). At the Norwegian Dry Eye Clinic, patients with symptomatic DED with different etiologies were consecutively included in the study. The patients underwent a comprehensive ophthalmological work-up and completed self-questionnaires on symptoms of ocular dryness (Ocu...

The differentiation and senescence programs of metazoans play key roles in regulating normal development and preventing aberrant cell proliferation, such as cancer. These programs are intimately associated with both the mitotic and apoptotic pathways. Caspase-8 is an apical apoptotic initiator that has recently been appreciated to coordinate non-apoptotic roles in the cell. Most of these functi...