نتایج جستجو برای: روش تحلیل عملکرد چشمانداز lfa

تعداد نتایج: 491099  

2002
Steven D. Marlin

Cell adhesion molecules are thought to play an important role in guiding cell migration and localization in the development of the embryo and in organogenesis. In the immune system, cell adhesion molecules enhance the efficiency of specific receptor-dependent lymphocyte-accessory cell and lymphocyte-target cell interactions ; they are also important in leukocyteendothelial cell interactions and...

Journal: :Blood 2004
Omar D Perez Dennis Mitchell Gina C Jager Garry P Nolan

Leukocyte function antigen 1 (LFA-1) is essential for the formation of immune cell synapses and plays a role in the pathophysiology of various autoimmune diseases. We investigated the molecular details of LFA-1 activation during adhesion between cytotoxic cells and a target model leukemia cell. The cytolytic activity of a CD3-CD8+CD56+ natural killer (NK) subset was enhanced when LFA-1 was acti...

Journal: :Journal of immunology 2006
William T N Simonson Santos J Franco Anna Huttenlocher

The leukocyte integrin LFA-1 plays a critical role in T cell trafficking and T cell adhesion to APCs. It is known that integrin-mediated adhesion is regulated by changes in integrin ligand-binding affinity and valency through inside-out signaling. However, the molecular mechanisms involved in TCR-mediated LFA-1 regulation are not well understood. In this study, we show that the cytoskeletal pro...

2011
Silvia Rossi Paccani Francesca Finetti Marilyne Davi Laura Patrussi Mario M. D'Elios Daniel Ladant Cosima T. Baldari

The Bordetella pertussis adenylate cyclase toxin (CyaA) assists infection by potently suppressing the host immune response. Although CyaA effectively targets T lymphocytes, its putative receptor on these cells is unknown. Here, we show that CyaA binds to T cells via the β₂ integrin LFA-1 in its active conformation. CyaA clusters with LFA-1 at the immune synapse (IS), from which it induces the p...

2015
Hua-Rong Huang Li-Chao Fan Bhavana Rajbanshi Jin-Fu Xu

BACKGROUND A new lateral flow immunoassay (LFA) for the detection of cryptococcal antigen was developed. OBJECTIVE We aimed to systematically review all relevant studies to evaluate the diagnostic accuracy of the cryptococcal antigen LFA on serum, CSF and urine specimens. METHODS We searched public databases including PubMed, Web of Science, Elsevier Science Direct and Cochrane Library for ...

Journal: :Journal of immunology 1995
A Yokota N Murata O Saiki M Shimizu T A Springer T Kishimoto

The integrin LFA-1 (CD11a/CD18) is a cell surface adhesion molecule required for leukocyte extravasation and subsequent immune and inflammatory responses. Rapid transition between nonadherent and adherent states of LFA-1 is of key importance to Ag-specific recognition of T lymphocytes. In this paper, LFA-1-mediated adhesiveness of peripheral blood (PB) and synovial fluid (SF) T lymphocytes to a...

Journal: :Journal of immunology 2000
A Sigal D A Bleijs V Grabovsky S J van Vliet O Dwir C G Figdor Y van Kooyk R Alon

The LFA-1 integrin is crucial for the firm adhesion of circulating leukocytes to ICAM-1-expressing endothelial cells. In the present study, we demonstrate that LFA-1 can arrest unstimulated PBL subsets and lymphoblastoid Jurkat cells on immobilized ICAM-1 under subphysiological shear flow and mediate firm adhesion to ICAM-1 after short static contact. However, LFA-1 expressed in K562 cells fail...

Journal: :Blood 2011
Rachel Evans Annemarie C Lellouch Lena Svensson Alison McDowall Nancy Hogg

The integrin lymphocyte function-associated antigen 1 (LFA-1) controls many functions of T lymphocytes and is particularly essential during lymphocyte migration from blood into tissues. LFA-1 is considered to initiate "outside-in" signaling when bound to ligand intercellular adhesion molecule 1 (ICAM-1), but little is known about the proteins involved or where in the cell such LFA-1-mediated si...

Journal: :The Journal of Experimental Medicine 2004
Sunil K. Shaw Shuo Ma Michael B. Kim Ravi M. Rao Charles U. Hartman Richard M. Froio Lin Yang Todd Jones Yuan Liu Asma Nusrat Charles A. Parkos F. William Luscinskas

The leukocyte integrin lymphocyte function-associated antigen 1 (LFA-1) and its endothelial ligand intercellular adhesion molecule (ICAM)-1 play an important role in transmigration as demonstrated by in vivo and in vitro models of inflammation. Despite the prominent role, little is known concerning the distribution and dynamic behavior of these adhesion molecules during leukocyte transmigration...

Journal: :Journal of immunology 1988
N Hollander P Selvaraj T A Springer

Mutants that lack expression of phosphatidylinositol (PI)-anchored proteins were derived from the human B lymphoblastoid JY cell line. It was demonstrated that unlike wild-type cells, which normally express both a transmembrane and a PI-linked form of LFA-3 glycoprotein, the mutant cells expressed only the transmembrane form of LFA-3. [3H]Ethanolamine was not incorporated into LFA-3 of mutant c...

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