Dear Sir, Carcinoma of unknown primary (CUP) represents a heterogeneous group of metastatic tumors where, even after a complete diagnostic workup the site of origin of the tumor is not detected. The diagnosis of CUP should be made after complete clinical history, physical examination, routine laboratory tests, imaging, and a careful review of the histology, and sometimes radio-metabolic techniq...

A method is described for estimating the amplitude modulation (AM) and the frequency modulation (FM) of the components of a signal that consists of two AM–FM sinusoids. The approach is based on the transduction of FM to AM that occurs whenever a signal of varying frequency passes through a filter with a nonflat frequency response. The objective is to separate the AM and FM of the sinusoids from...

BACKGROUND The fragrance mix (FM I), established in 1977, detects the majority, but not all cases of contact allergy to fragrances. Based on European research 2002/2003, fragrance mix II (FM II) was developed to supplement FM I. In 2005, the German Contact Dermatitis Research Group (DKG) added FM II to their baseline series. OBJECTIVES To evaluate reactions to FM II and its constituents in ro...

BACKGROUND Fibromyalgia (FM) is common in older adults suffering from mood disorders. However, clinical diagnosis of FM is challenging, particularly in psychiatric settings. We examined the prevalence of FM and the sensitivity of three simple screeners for FM. METHODS Using cross-sectional data, we evaluated three tests against the American College of Rheumatology (ACR) 1990 Criteria for the ...

Fibromyalgia (FM) and transformed migraine (TM) are common chronic pain disorders. The authors estimated the prevalence of FM in 101 patients with TM, and analyzed its relationship to depression, anxiety, and insomnia. FM was diagnosed in 35.6% of cases. Patients with FM had more insomnia, were older, and had headaches that were more incapacitating than patients without FM. Insomnia and depress...

Do 18-month-olds understand that an agent's false belief can be corrected by an appropriate, though not an inappropriate, communication? In Experiment 1, infants watched a series of events involving two agents, a ball, and two containers: a box and a cup. To start, agent1 played with the ball and then hid it in the box, while agent2 looked on. Next, in agent1's absence, agent2 moved the ball fr...

INTRODUCTION Fibromyalgia (FM) is mainly characterized by widespread pain and multiple accompanying symptoms, which hinder FM assessment and management. In order to reduce FM heterogeneity we classified clinical data into simplified dimensions that were used to define FM subgroups. MATERIAL AND METHODS 48 variables were evaluated in 1,446 Spanish FM cases fulfilling 1990 ACR FM criteria. A pa...

Let FM(A), for A = (ω, R̄), be the family of finite models being initial segments of A. The thesis investigates logical properties of families of the form FM(A) for various arithmetics like arithmetic of addition and multiplication, Skolem arithmetic of multiplication, arithmetic of coprimality, of exponentiation and arithmetic of concatenation. We concentrate on questions such as decidability o...

OBJECTIVES To evaluate plasma amino acid (AA) concentrations in patients affected by fibromyalgia (FM) and to study the relationships between their levels and FM clinical parameters. DESIGN AND METHODS 20 AAs were assessed in 34 FM patients and in 18 healthy volunteers by means of a modified version of the Waters picotag method. RESULTS Significant lower plasma taurine, alanine, tyrosine (T...