Bj Samar Aboulsoud Qatar Terrence Adam United States of America Sara Ahmadi United States of America Peter Aitken Australia César Alameda Spain Yavuz Albayrak Turkey Gidon Almogy Israel Tore Amundsen Norway Hagen Andruszkow Germany Filip K. Arnberg Sweden Takashi Asai Japan M Hammad Ather Pakistan Matt Baker United Kingdom Miklosh Bala Israel Chad Ball Canada Angela Bång Sweden Charlotte Barfod...

Gabriella D’Angelo1*, Lucia Marseglia1, Sara Manti2, Pietro Impellizzeri3, Carmelo Salpietro2, Eloisa Gitto1 and Carmelo Romeo3 1Neonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, Italy 2Unit of Paediatric Genetics and Immunology, Department of Paediatrics, University of Messina, Italy 3Unit of Paediatric Surgery, Department of Paediatrics, University o...

Urinary Tract Infection (UTI) is a globally widespread human infection caused by an infestation of uropathogens. Eventhough, Escherichia coli is often quoted as being the chief among them, Staphylococcus aureus involvement in UTI especially in gestational UTI is often understated. Staphylococcal accessory regulator A (SarA) is a quorum regulator of S. aureus that controls the expression of vari...

BACKGROUND The prevalence and the clinical consequences of subacute ruminal acidosis (SARA) in dairy cows are still poorly understood. In order to evaluate the prevalence of SARA, 26 German dairy farms were included in a field study. In each herd, between 11 and 14 lactating dairy cows were examined for their ruminal pH using rumenocentesis. Milk production data and farm management characterist...

Effects of a bacterial probiotic (BP) on ruminal fermentation and plasma metabolites were evaluated in four Holstein cattle (body weight, 645 ± 62 kg; mean ± SD) with induced subacute ruminal acidosis (SARA). SARA was induced by feeding a SARA-inducing diet, and thereafter, 20, 50 or 100 g per head of a commercial BP was administered for 7 consecutive days during the morning feeding. Cattle wit...

Recent studies have uncovered a key role of endocytosis during Notch signalling after the asymmetric division of the fly sensory organ precursor cells (SOP): directional signalling is mediated by differential endocytosis of the ligand Delta and the Notch effector Sanpodo in one of the SOP daughters, the pIIb. Here we show a novel mechanism of directional signalling based on the trafficking of D...

Staphylococcus aureus is a widely acknowledged Gram-positive pathogen for forming biofilm and virulence gene expressions by quorum sensing (QS), a cell to cell communication process. The quorum regulator SarA of S. aureus up-regulates the expression of many virulence factors including biofilm formation to mediate pathogenesis and evasion of the host immune system in the late phases of growth. T...

Staphylococcal protein A (Spa) is an important virulence factor of Staphylococcus aureus. Transcription of the spa determinant occurs during the exponential growth phase and is repressed when the cells enter the postexponential growth phase. Regulation of spa expression has been found to be complicated, with regulation involving multiple factors, including Agr, SarA, SarS, SarT, Rot, and MgrA. ...

SarA, a Staphylococcus aureus-specific dimeric protein, modulates the expression of numerous proteins including various virulence factors. Interestingly, S. aureus synthesizes multiple SarA paralogs seemingly for optimizing the expression of its virulence factors. To understand the domain structure/flexibility and the folding/unfolding mechanism of the SarA protein family, we have studied a rec...