The aim of this study was to clarify the relationship between dioxin concentrations in breast milk and the sister chromatid exchange (SCE) frequency in women from herbicide-sprayed and non sprayed areas. Blood samples were taken from 21 women with high TCDD (tetrachlorodibenzo-p-dioxin) levels from sprayed areas, 23 women with moderate TCDD levels from sprayed areas, and 19 women from non spray...

Submitted for publication: September 10, 2009 Accepted for publication: January 5, 2010 The adoption in 2000 of the Common Technical Document (CTD) format for marketing applications notwithstanding, the US regulations requiring an integrated summary of effectiveness (ISE) and an integrated summary of safety (ISS) remain in effect. Many applicants, however, have attempted to use the CTD module 2...

Intercalator-induced DNA strand breaks in mammalian cells represent topoisomerase II:DNA complexes trapped by intercalators. These complexes are detected as protein-associated DNA single-strand breaks (SSB) and DNA double-strand breaks (DSB) by filter elution. Using Chinese hamster lung fibroblasts (V79 cells) that were treated for 30 min with various concentrations of 4'-(9-acridinylamino)meth...

GENETIC TOXICITY S_'JDIES OF ORGANIC CHEMICALS FOUND AS CONTAMINANTS IN SPACECRAFT CABIN ATMOSPHERES Joseph Torres Jr., Ph.D. Assistant Professor Department of Biological Sciences Southeastern Louisiana University ABSTRACT Astronauts can be exposed during spaceflight to organic chemical contaminants in the spacecraft cabin atmosphere. Toxic exposures may cause lesions in the cellular DNA which ...

BACKGROUND The scaling exponent (ScE) of the ventricular fibrillation (VF) waveform correlates with duration of VF and predicts defibrillation outcome. We compared 4 therapeutic approaches to the treatment of VF of various durations. METHODS AND RESULTS Seventy-two swine (19.5 to 25.7 kg) were randomly assigned to 1 of 9 groups (n=8 each). VF was induced and left untreated until the ScE reach...

PURPOSE Anti-vascular endothelial growth factor (VEGF) antibody therapy is an effective treatment for ocular angiogenesis. Although the intraocular pressure of some patients increases after anti-VEGF therapy, the effects of VEGF-A on the aqueous humor outflow pathway remain unknown. This study investigated the effects of VEGF-A on the aqueous humor outflow pathway. METHODS We used human recom...

This study is investigated the optimum parameters for a tuned mass damper (TMD) under the seismic excitation. Shuffled complex evolution (SCE) is a meta-heuristic optimization method which is used to find the optimum damping and tuning frequency ratio for a TMD. The efficiency of the TMD is evaluated by decreasing the structural displacement dynamic magnification factor (DDMF) and acceleration ...

Subcutaneous emphysema (SCE) mimicking diaphragmatic hernia on X-ray is hitherto unreported and this case has been presented with the aim to alert the clinician about this unusual presentation of SCE to avert undue panic and initiate appropriate evaluation and management. This case also reemphasizes the importance of a thorough clinical examination, which probably could have revealed the subcut...

Topiramate ( sulfamate - substituted monosaccharide) a weight loss drug used pharmacotherapeutic agent for obesity , study was performed to evaluate the effect of topiramate induce chromosome aberrations (CA) and sister chromatid exchange (SCE) in lymphocytes patients . CA SCE, sensitive measure damage were counted peripheral blood from 32 treated with dose 6 months 81mg/day 12 129 mg/day) 16 h...

It is proved, that the recently discussed Appell polynomials in Clifford algebras are the Fueter-Sce extension of the complex monomials z. Furthermore, it is shown, for which complex functions the Fueter-Sce extension and the extension method using Appell polynomials coincide.