Typical features of the Transmission Line Matrix (TLM) algorithm in connection with stub loading techniques and prone to be hidden by common frequency domain formulations are elucidated within the propagator approach. In particular, the latter reflects properly the perturbative character of the TLM scheme and its relation to gauge field models. Internal ‘gauge’ degrees of freedom are made expli...

The biosynthetic gene clusters for the glycopeptide antitumor antibiotics bleomycin (BLM), tallysomycin (TLM), and zorbamycin (ZBM) have been recently cloned and characterized from Streptomyces verticillus ATCC15003, Streptoalloteichus hindustanus E465-94 ATCC31158, and Streptomyces flavoviridis ATCC21892, respectively. The striking similarities and differences among the biosynthetic gene clust...

A widely used approach for the simulation of vocal tract acoustics is the transmission line model (TLM) with lumped elements [2, 3]. The TLM is based on onedimensional acoustic propagation in a tube with a piecewise constant cross-sectional area. The governing equations for the TLM were originally derived under the following assumptions: The sound field causes only small perturbations of the th...

Objectives. To assess the outcome of transoral laser-assisted microsurgery (TLM) with regards to local and distant tumour control, quality of voice and swallowing. Design. Retrospective review of patients with five-year follow-up period. Setting. Royal Derby Hospital Head and Neck Department. Participants. All patients undergoing TLM with a diagnosis of Tis, T1, or T2 glottic tumour following e...

OBJECTIVES/HYPOTHESIS Evaluate the oncologic outcomes of patients with early and select advanced primary glottic squamous cell carcinoma (SCCa) managed by transoral laser microsurgery (TLM). STUDY DESIGN Retrospective cohort study. METHODS Ninety cases of TLM-managed primary glottic SCCa were identified retrospectively using a prospectively collected database. RESULTS Outcomes of patients...

BACKGROUND The purpose of this study was to report the treatment outcomes of patients with advanced oropharyngeal cancer treated with transoral laser microsurgery (TLM) followed by radiation therapy (RT) at Mayo Clinic in Arizona. METHODS A retrospective study of 80 patients treated from January 1, 2000 to November 7, 2011 was performed. All patients had stage III/IV oropharyngeal tumors and ...

System-on-Chip (SoC) designs are increasingly becoming more complex. Efficient on-chip communication architectures are critical for achieving desired performance in these systems. System designers typically use Bus Cycle Accurate (BCA) models written in high level languages such as C/C++ to explore the communication design space. These models capture all of the bus signals and strictly maintain...

We have investigated the site-specific cleavage of DNA by the antitumor antibiotics talisomycin and bleomycin by using 5'or 3'-terminal 32P-labeled restriction fragments of pBR 322 DNA. Both drugs cleaved DNA preferentially at G-C and G-T sequences. However, the relative amounts of cleavage at par ticular cleavage sites differed between talisomysin and bleo mycin at concentrations of the drugs ...