PURPOSE Uveal melanoma (UM) is the most common primary malignant ocular tumor in adults. No effective chemotherapy regimens are available for either intraocular or metastatic uveal melanoma. Therefore, the ability of the histone deacetylase inhibitors (HDACIs), depsipeptide, sodium butyrate (NaB) and trichostatin A (TSA), to induce apoptosis and inhibit cell growth of UM cell lines in vitro was...

Accumulating evidence shows that androgen receptor (AR) activation and signaling plays a key role in growth and progression in all stages of prostate cancer, even under low androgen levels or in the absence of androgen in the castration-resistant prostate cancer. Sustained activation of AR under androgen-deprived conditions may be due to its interaction with co-activators, such as p52 NF-κB sub...

The development of oil and gas production together with the fruit in nearby areas North Patagonia, Argentina, suggests aquatic pollution scenarios which include permanent combined short events pesticides application. It has been reported that hydrocarbons activate aryl hydrocarbon receptor (AhR) pathway rainbow trout, Oncorhynchus mykiss, insecticide Chlorpyrifos (CPF) interacts these effects. ...

کاربرد نیروهای لورنتز ناشی از میدان های الکترومغناطیس در کنترل جریان روش مناسب و مورد توجهی می­باشد. این نیرو در فرآیند حل عددی به صورت جمله­های چشمه به معادلات حرکت سیال اضافه می­شود. با این پدیده، مدلسازی عددی جریان فرو صوت با عدد ماخ 2/0 برای رژیم آشفته توسط روش حجم محدود tvd و با پیشروی زمانی ضمنی برای حل معادلات دو بعدی تراکم پذیر ناویر-استوکس جریان سیال و با مدل آشفتگی بالدوین-لومکس در اط...

Multi-terminal high-voltage direct current technology based on voltage-source converter stations (VSC-MTDC) is expected to be one of the most important contributors future electric power systems. In fact, among other features, it has already been shown how this can contribute improve transient stability in systems by use supplementary controllers. Along line, paper will investigate detail these...

Acute catastrophic events can cause significant damage to marine environments in a short time period and may have devastating long-term impacts. In April 2010 the BP-operated Deepwater Horizon (DWH) offshore oil rig exploded, releasing an estimated 760 million liters of crude oil into the Gulf of Mexico. This study examines the potential effects of oil spill exposure on coral larvae of the Flor...

BACKGROUND DNA damage in mammalian cells stabilizes the p53 protein which then functions as a cell cycle checkpoint by leading to growth arrest or apoptosis. p53 is a transcription factor and positively regulates the expression of the p21/WAF-1 gene and the mdm2 gene. After high-dose UV irradiation, p53 increases the expression of the p21/WAF-1 gene immediately (2 to 5 hours after irradiation) ...

Abstract The Montney tight siltstone reservoir is a multi-stacked play, which covers total area of 130,000 km 2 along the Alberta–British Columbia border in Western Canada. Since late 1990s, different fracturing methods and fluids have been tested 4000-plus wells to find optimal method fluid. previous studies reviewing performance do not represent holistic evaluation these methods, owing some l...

INTRODUCTION Selection of resistance mutations on antiretroviral therapy (ART) including darunavir (DRV/r) or atazanavir (ATV/r) has been reported infrequently but mainly in clinical trials where patients were followed very frequently (at least four to five clinical visits and viral load measurements per year). The aim of this study was to evaluate the rate of resistance at failure and mutation...