Stevens et al suggest that the Modification of Diet in Renal Disease (MDRD) Study equation for estimated glomerular filtration rate (GFR) is an acceptable substitute for estimated or measured creatinine clearance (CCr) as an index for adjusting drug doses in patients with chronic kidney disease and acute kidney injury. However, others have raised concerns that injudicious use of estimated GFR a...

Abstract: The radial measures of classical DEA models (CCR, BCC) are incomplete, they are only separate measures of input and output efficiency and their efficiency index omit the non-zero input and output slacks. Enhanced Russell graph measure (ERM) eliminates these deficiencies. All of the existing fuzzy DEA models are extension of CCR or BCC model, efficiencies of DMUs, ultimately, are solut...

A major obstacle to presymptomatic diagnosis and disease-modifying therapy for Alzheimer's disease (AD) is inadequate understanding of molecular mechanisms of AD pathogenesis. For example, impaired brain insulin signaling is an AD hallmark, but whether and how it might contribute to the synaptic dysfunction and neuron death that underlie memory and cognitive impairment has been mysterious. Neur...

Can creatinine clearance in children clear the indexing GFR with BSA from the charge of errors? We read with interest the article of Delanaye and colleagues stating that indexing glomerular filtration rate (GFR) with body surface area (BSA) required mathematical prerequisites to be satisfied, even though many studies reported they were not [1]. Although not the gold standard to measure GFR, cre...

The pharmacokinetics of netilmicin were examined in 25 adult subjects, 7 normal subjects, and 18 patients with renal impairment. Five were dialysis patients who were studied on and off dialysis. Netilmicin, 2 mg/kg, was infused intravenously over 1 h. The peak serum concentration ranged from 9 to 11 mug/ml. The mean biological half-life of netilmicin for subjects with a creatinine clearance (Cc...

A computerized clinical reminder (CCR) system is a type of decision support tool to remind healthcare providers of recommended actions. In our prior study, we found a linear correlation between resolution time and adherence rate. This correlation implies a potentially biased clinical decision making. This study aimed to redesign the Veterans Affairs (VA) CCR system in order to improve providers...

BACKGROUND Recent studies have shown that a new emergency medical services (EMS) protocol for treating patients who suffer out-of-hospital cardiac arrest (OHCA), cardiocerebral resuscitation (CCR), significantly improves survival compared to standard advanced life support (ALS). However, due to their different physiology, it is unclear if all elders, or any subsets of elders who are OHCA victim...

Results of different types of treatment in 416 adults with chronic idiopathic thrombocytopenic purpura (ITP) were analyzed. Of 368 patients treated with corticosteroids, 278 (77%) achieved complete response (CR ie, normalization of platelet count). However, only 18% of patients had continued complete response (CCR). Results of splenectomy was analyzed in 126 patients, 49% of them achieved CCR a...

BACKGROUND Interest in health information exchanges (HIEs) is increasing. Several countries have adopted core health data standards with appropriate strategies. OBJECTIVE This study was conducted to determine the feasibility of a continuity of care record (CCR) as the standard for an electronic version of the official transfer note and the HIE in Korean healthcare. METHOD A technical review...

OBJECTIVE Computerized clinical reminder (CCR) systems can improve preventive service delivery by providing patient-specific reminders at the point of care. However, adherence varies between individual CCRs and is correlated to resolution time amongst other factors. This study aimed to evaluate how a proposed CCR redesign providing information explaining why the CCRs occurred would impact provi...