Glucocorticoids (GCs) are the mainstay of anti-inflammatory therapy. Modulation of posttranscriptional regulation (PTR) of gene expression by GCs is a relevant yet poorly characterized mechanism of their action. The RNA-binding protein tristetraprolin (TTP) plays a central role in PTR by binding to AU-rich elements in the 3'-untranslated region of proinflammatory transcripts and accelerating th...

AIMS CD36-mediated uptake of oxidized low-density lipoprotein (oxLDL) plays a pivotal role in macrophage foam-cell formation and atherogenesis. Previously we reported on intermedin (IMD), a novel member of the calcitonin gene-related peptide family, in atherosclerotic plaque reducing atherogenesis in apolipoprotein E-deficient (apoE(-/-)) mice. Here, we studied the role of IMD in CD36-mediated ...

We describe a case of severe myocardial ischaemia in the setting of thrombotic thrombocytopoenic purpura (TTP). In this report, we discuss the potential difficulties in the diagnosis and management of acute myocardial ischaemia with TTP, particularly relating to the use of antiplatelet agents. We also highlight the importance of careful monitoring during plasma exchange for TTP when acute myoca...

Thrombotic thrombocytopenic purpura (TTP) in pregnancy is rare, and can be a diagnostic challenge because of its clinical similarity to pre-eclamptic disorders. Without treatment, mortality rate of TTP is more than 90%, therefore early recognition of TTP is important. Treatment with plasma transfusions and plasmapheresis decreases the mortality rate to 20% [1]. We report a case of TTP discovere...

The Traveling Thief Problem (TTP) is a novel problem that combines the well-known Traveling Salesman Problem (TSP) and Knapsack Problem (KP). In this paper, the complexity of the local-searchbased heuristics for solving TTP is analyzed, and complexity reduction strategies for TTP are proposed to speed up the heuristics. Then, a two-stage local search process with fitness approximation schemes i...

Mitochondrial dynamics play critical roles in maintaining mitochondrial functions. Here, we report a novel mechanism for regulation of mitochondrial dynamics mediated by tristetraprolin (TTP), an AU-rich element (ARE)-binding protein. Overexpression of TTP resulted in elongated mitochondria, down-regulation of mitochondrial oxidative phosphorylation, reduced membrane potential, cytochrome c rel...

Automatic (i.e., computer-assisted) theorem proving (ATP) can come in many flavors. This document presents early steps in our effort towards defining object-oriented theorem proving (OOTP) as a new style of ATP. Traditional theorem proving (TTP) is the only well-known flavor of ATP so far. OOTP is a generalization of TTP. While TTP is strongly based on functional programming (FP), OOTP is stron...

Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs) that recognize AU-rich elements (AREs) found within many transcripts. Analyses of precancerous and malignant Myc-expressing B cells revealed that Myc regulates hundreds of ARE-containing (ARED) ge...