multiple sclerosis (ms) is a demyelinating neuro- inflammatory autoimmune disease of the central nervous system. genetic predisposition has long been suspected in the etiology of this disease. the association between mthfr polymorphisms and ms has been ivestigated in different ethnic groups. we investigated the association between mthfr c677t and a1298c missense variants and ms in 180 patients ...

background:  the development of allergic rhinitis (ar) is caused by the interaction between genetic predisposition and environmental factors. in this study, the association between gata3 single nucleotide polymorphisms and ar in an iranian population was identified. methods:  this case-control study was performed on 86 patients with ar and 86 healthy subjects. this study aimed to evaluate a pot...

Amaç: Kalpain-10 (CAPN10), Ca+2 bağımlı intrasellüler sistein proteazlar ailesinin atipik bir üyesidir. Birçok dokuda eksprese edilir ve başta insülin sekresyonu aktivitesi olmak üzere çok çeşitli hücresel fonksiyonlar için gereklidir. Tanımlanan ilk Tip 2 diyabet (T2D) yatkınlık genidir. Çalışmamızda Türk popülasyonunda CAPN10 gen polimorfizmleri (SNP-44, -43 -137) ile artmış T2D riski arasınd...

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Genome-wide association studies are likely to be conducted in large scale in the near future. In such studies, searching over hundreds of thousands of markers for the few ones that are associated with disease brings out the multiple-hypothesis testing problem in its severe form. We explore, in a two-stage design, how the use of false discovery rate (FDR) can alleviate the burden of a prohibitiv...

conclusions simpleprobe® real-time pcr is a fast and accurate technique qualified to detect vkorc1 and cyp2c9 snps. these results encourage taking further steps towards using vkorc1 and cyp2c9 allelic screening to prevent clinical complications due to resistance or sensitivity to warfarin as well as anti-coagulant dose adjustment. results the allelic frequencies for vkorc1 c1173t (cc, ct, tt) w...

copper is a micronutrient which its, deficiency can alter essential functions in plant metabolism. on the other hand, excess copper is present in certain regions and environments, and can be potentially toxic to plants causing phytotoxicity by the formation of reactive oxygen species that damage cells. in this study, we examined the effect interactions between various concentrations of sodium n...