نتایج جستجو برای: شاخص ed50
تعداد نتایج: 76082 فیلتر نتایج به سال:
The steroidogenic properties of a glycoprotein fraction (urinary ASF), isolated from normal human urine, were studied in collagenase-dispersed rabbit adrenal capsular cells in 1) define the requirements for its steroidogenic activity, and 2) assess its site and mode of action. When incubated with adrenal cell suspension at 37 degrees C for 2 hours, urinary ASF induced dose-related increases in ...
This is the first study to investigate the biological activities of fermented extracts of Rhodiola rosea L. (Crassulaceae) and Lonicera japonica Thunb. (Caprifoliaceae). Alcaligenes piechaudii CC-ESB2 fermented and ethanol extracts of Rhodiola rosea and Lonicera japonica were prepared and the antioxidative activities of different concentrations of samples were evaluated using in vitro antioxida...
P2X3 and P2X2/3 receptors are highly localized on peripheral and central processes of sensory afferent nerves, and activation of these channels contributes to the pronociceptive effects of ATP. A-317491 is a novel non-nucleotide antagonist of P2X3 and P2X2/3 receptor activation. A-317491 potently blocked recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22-92 nM) an...
We examined the effects of YM020 (3-cyanomethyl-2-methyl-8-[(3-methyl-2-butenyl)oxy]-imidazo[1,2- a]pyridine), a novel H+,K(+)-ATPase inhibitor, on gastric acid secretion and experimental gastroduodenal lesions in rats and dogs. Intraduodenal, subcutaneous and oral YM020 inhibited basal gastric acid secretion in pylorus-ligated rats with ED50 values of 9.1, 9.1 and 9.5 mg/kg, respectively. Oral...
The study describes a model of chronic intestinal inflammation in mice. Inflammation was induced by the administration of one dose of croton oil (CO) (acute CO) or two doses (chronic CO) of intragastric CO, whereas controls received saline (SS); GI transit was measured with charcoal. Chronic CO induced intestinal inflammation substantiated by optical microscopy, weight loss (20%) and a 25% incr...
Background: Leishmaniasis is a parasitic disease originated from species of the genus Leishmania from the Trypanosomatidae family, with three main clinical forms of cutaneous, mucocutaneous and visceral. Every year, many new cases of the disease are reported in endemic areas. Nowadays, in non-endemic regions, the incidence of the disease has also created tension. Medicine side effects, reports ...
جهت تعیین میزان دوز کشنده (LD50) سم مار شاخدار ایرانی و به دنبال آن تعیین دوز موثر (ED50) پادزهر (آنتی ونوم) آن، ابتدا غلظت پروتئینهای سم مارشاخدار به روش Lowry و با استفاده از پروتئین استاندارد BSA تعیین گردید که میزان آن برابر باµg/ml 1500 گزارش گردید. سپس برای اندازهگیری میزان کشندگی سم مار، در شش سطح، از موشهای آزمایشگاهی تیپ BALB/c استرالیایی جنس ماده با وزن gr 20-18 استفاده گردید. همچن...
The response of RIMI [imazethapyr-tolerant (T)] sunflower (Helianthus annuus L.) hybrid and the local imazethapyr-sensitive hybrid "Zoltan" (S) was investigated under controlled conditions. Hybrids grown in pots were treated post-emergence with imazethapyr at the two pairs of leaves stage. Visual injury evaluation and vegetative parameters were recorded. ALS (acetolactate synthase) enzyme activ...
ED50 of propofol in combination with low‐dose sufentanil for intravenous anaesthesia in hysteroscopy
زمینه : تحقیقات نشان داده است که سن در تغییر پاسخ دهی به داروها نقش مهمی دارد. هدف : مطالعه به منظور تعیین اثر سن بر سیستم کولینرژیک و آدرنرژیک دهلیز مجزای رت انجام شد. مواد و روش ها: در این مطالعه تجربی دهلیز جدا شده رت های 10 تا 20 روزه (گروه اول), 2 ماهه (گروه دوم ) و بالای شش ماه (گروه سوم ) از نژاد اسپیراگ داولی نوع آلبینو به تعداد هر گروه 6 تا 10 رأس به طور تصادفی انتخاب و پاسخ های انقباض...
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