We consider a few applications of Mañé’s C2 Connecting Lemma. These are the C2 creation of homoclinic points associated to a basic set (i.e., isolated transitive hyperbolic set), a C2 locally generic criterion to know whether a given point belongs to the stable set of hyperbolic homoclinic classes, and that measurably hyperbolic diffeomorphisms (i.e., having the closure of supports of all invar...

Abstract We report the application of Pd(II)-catalyzed, directing-group-aided C–H arylation/alkylation tactics to functionalize pyrene core, especially, relatively inaccessible C2 and K-region C10 positions core augmentation library derivatives with C1,C2- C1,C10-disubstituted motifs. The Pd(II)-catalyzed β-C–H C2-position pyrene-1-carboxamide possessing an 8-aminoquinoline directing group yiel...

A case of C2 deficiency presenting with disseminated gonococcal infection is described. The predisposition of C2-deficient individuals to infection in addition to the commoner problem of immune complex diseases is noted. Attention is drawn to the absence of documented cases of gonococcal infection associated with C2 deficiency. No other homozygous C2 deficient family members were identified. Li...

This thesis demonstrates that perception plays a role in computing grammatical wellformedness. This is shown specifically for grammatical constraints on word-final consonant cluster inventories (VC 1 C2#), with focus on coda cluster simplification in Trinidad English. The first claim of this thesis is that C2 deletion is triggered when VC 1 C2# is not sufficiently distinguished perceptually fro...

Calponin contributes to the regulation of smooth muscle contraction through its interaction with F-actin and inhibition of the actin-activated Mg-ATPase activity of phosphorylated myosin. Previous studies have shown that the contractile agonist acetylcholine induced a direct association of translocated calponin and PKC-alpha in the membrane. In the present study, we have determined the domain o...

The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy for hemophilia A patients, or they may spontaneously arise in cases of acquired hemophilia. Porcine factor VIII is an effective therapeutic fo...

Somara S, Bitar KN. Direct association of calponin with specific domains of PKC. Am J Physiol Gastrointest Liver Physiol 295: G1246 –G1254, 2008. First published October 23, 2008; doi:10.1152/ajpgi.90461.2008.—Calponin contributes to the regulation of smooth muscle contraction through its interaction with F-actin and inhibition of the actin-activated Mg-ATPase activity of phosphorylated myosin....