Rhabdomyosarcoma (RMS) is a childhood cancer originating from skeletal muscle, and patient survival is poor in the presence of metastatic disease. Few determinants that regulate metastasis development have been identified. The receptor tyrosine kinase FGFR4 is highly expressed in RMS tissue, suggesting a role in tumorigenesis, although its functional importance has not been defined. Here, we re...

Exploiting the lytic life cycle of viruses has gained recent attention as an anticancer strategy (oncolysis). To explore the utility of adenovirus (Ad)-mediated oncolysis for rhabdomyosarcoma (RMS), we tested RMS cell lines for Ad gene transduction and infection. RMS cells were variably transduced by Ad. Compared with control cells, RMS cells were less sensitive or even resistant to oncolysis b...

We observed that human rhabdomyosarcoma (RMS) cells highly express a tissue factor that promotes thrombin formation, which indirectly and directly affects RMS progression. First, we found that thrombin activates platelets to generate microvesicles (PMV), which transfer to RMS cells' alpha2beta3 integrin and increase their adhesiveness to endothelial cells. Accordingly, RMS cells covered with PM...

Rhabdomyosarcoma (RMS) is a malignant skeletal muscle neoplasm. RMS can occur anywhere in the body and is the most common childhood sarcoma (1). Pediatric RMS is an aggressive neoplasm with deregulated cell cycle checkpoints, high genome instability, and oncongene ampli ication such as MYC family members (2). However, RMS rarely occurs in adults. Moreover, sarcomas of the kidney are rare soft t...

We define Recursive Matrix Systems (RMS), a highly parameterizable formalism that allows for a clear separation of various kinds of recursion. One instance of RMS, namely context-free RMS with two rows and a specific reading interpretation turns out to be weakly equivalent to TAG. This allows for the transfer ofresults from TAGs to this dass of RMS. Furthermore, the equivalence proof is constru...

A Computer-Aided-Test (CAT) platform has been integrated in the Cadence Design Framework Environment for the evaluation of analogue/mixed-signal/RF Built-In-Self-Test (BIST) techniques. It comprises tools for statistical modelling of circuit performances, fault simulation, test generation and test optimization. The fault modelling and fault injection tools are simulator-independent, thus they a...

Rhabdomyosarcomas (RMS) bear a morphological resemblance to developing striated muscle. It has been reported that two histologically distinct subtypes of RMS, embryonal and alveolar, behave differently in many clinical aspects, such as age distribution, primary site, and prognosis. We have investigated the expression of various genes, which are preferentially expressed in normal muscle tissue o...

Rhabdomyosarcomas (RMSs) are frequently characterized by bone marrow involvement. Recently, we reported that human RMS cells express the CXC chemokine receptor-4 (CXCR4) and postulated a role for the CXCR4 stromal-derived factor (SDF)-1 axis in the metastasis of RMS cells to bone marrow. Because RMS cells also express the tyrosine kinase receptor c-MET, the specific ligand hepatocyte growth fac...

The objective of this study was to investigate whether stressful experience during early postnatal period may influence morphological characteristics of the rat neurogenic pathway--the rostral migratory stream (RMS) and proliferation of neuronal precursors in three successive areas of the RMS: in the vertical arm, the elbow and the horizontal arm. To induce stress, the pups were subjected to re...