Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by delayed/abnormal language development, deficits in social interaction, repetitive behaviors and restricted interests. The heterogeneity in clinical presentation of ASD, likely due to different etiologies, complicates genetic/biological analyses of these disorders. DNA microarray analyses were conducted on 116 lymp...

BACKGROUND Total knee arthroplasty in joints with valgus or varus deformity is technically demanding. Careful soft tissue balance as well as restitution of anatomical knee axis has a profound effect on postoperative function of the joint, however little is known about differences in subjective stability following surgery between preoperative valgus and varus knees. MATERIAL AND METHODS Studie...

Super-enhancers are clusters of gene-regulatory sites bound by multiple transcription factors that govern cell transcription, development, phenotype, and oncogenesis. By examining Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs), we identified four EBV oncoproteins and five EBV-activated NF-κB subunits co-occupying ∼1,800 enhancer sites. Of these, 187 had markedly higher an...

-The use of power converters is very important in maximizing the power transfer from renewable energy sources such as wind, solar, or even a hydrogen-based fuel cell to the utility grid. A LCL filter is often used to interconnect an inverter to the utility grid in order to filter the harmonics produced by the inverter. Even though there is an extensive amount of literature available describing ...

Natural killer (NK) cells kill normal and transformed hematopoietic cells that lack expression of major histocompatibility complex (MHC) class I antigens. Lysis of HLA-negative Epstein Barr virus-transformed B lymphoblastoid cell lines (B-LCL) by human NK cell clones can be inhibited by transfection of the target cells with certain HLA-A, -B, or -C alleles. NK cell clones established from an in...

In order to evaluate the contribution of the knee ligaments to restrain joint motions, knowledge about their structural properties is required. Due to the variable relative insertion orientation of the ligaments during knee motion, however, different fiber bundles are recruited, each with their specific mechanical properties. Hence, the structural properties vary as a function of knee motion. F...

The degree to which the level of genetic variation for gene expression is shared across multiple tissues has important implications for research investigating the role of expression on the etiology of complex human traits and diseases. In the last few years, several studies have been published reporting the extent of overlap in expression quantitative trait loci (eQTL) identified in multiple ti...

Locally Checkable Labeling (LCL) problems include essentially all the classic problems of LOCAL distributed algorithms. In a recent enlightening revelation, Chang and Pettie [arXiv 1704.06297] showed that any LCL (on bounded degree graphs) that has an o(log n)-round randomized algorithm can be solved in TLLL(n) rounds, which is the randomized complexity of solving (a relaxed variant of) the Lov...

Introduction. This study investigated the importance of the "oblique popliteal ligament" (OPL), and challenges its alleged ligament status. The currently named OPL is indigenous to the distal semimembranosus (SMT); therefore, by definition is not a ligament inserting from bone to bone. Clinically, a muscle-tendon unit is different then a ligament regarding proprioception and surgery. Methods. L...

Since its introduction by Bloembergen in 1949, nuclear spin diffusion has been a topic of significant interest in magnetic resonance. Spin diffusion, which can be defined as the transfer of spin polarisation induced by the dipolar interaction, is a ubiquitous transport mechanism in solids. Experimental observations of spin diffusion contain structural information. However, the many-body nature ...