In order to examine myoglobin (Mb) function and metabolic responses of seal muscle during progressive ischemia and hypoxemia, Mb saturation and high-energy phosphate levels were monitored with NMR spectroscopy during sleep apnea in elephant seals (Mirounga angustirostris). Muscle blood flow (MBF) was measured with laser-Doppler flowmetry (LDF). During six, spontaneous, 8-12 min apneas of an unr...

BACKGROUND Coronary abnormalities after Kawasaki disease (KD) may be associated with endothelial dysfunction due to intimal hypertrophy. The purpose of this study was to evaluate myocardial flow reserve (MFR) and endothelial function in regressed aneurysmal regions after KD. Methods and Results- Subjects were 12 patients aged 16.0+/-2.6 years who suffered from KD at 1.7+/-1.5 years and 12 norma...

We compared the effects of hypertonic saline 7.2%/6% hydroxyethyl starch (HSS-HES) and isotonic saline 0.9%/6% hydroxyethyl starch (ISS-HES) on ileal microcirculatory blood flow (MBF) at the initial phase of septic shock. Pigs were anesthetized and mechanically ventilated. Catheters were inserted into right atrium, pulmonary artery, carotid artery, and portal vein for hemodynamic measurements a...

To examine the functional interaction between superoxide dismutase (SOD) and NADPH oxidase activity, we assessed renal responses to acute intra-arterial infusion of ANG II (0.5 ng x kg(-1) x min(-1)) before and during administration of a SOD inhibitor, diethyldithiocarbamate (DETC, 0.5 mg x kg(-1) x min(-1)), in enalaprilat-pretreated (33 microg x kg(-1) x min(-1)) rats (n = 11). Total (RBF) an...

Myocardial blood flow (MBF) can be estimated from dynamic contrast enhanced (DCE) cardiac CT acquisitions, leading to quantitative assessment of regional perfusion. The need for low radiation dose and the lack of consensus on MBF estimation methods motivates this study to refine the selection of acquisition protocols and models for CT-derived MBF. DCE cardiac CT acquisitions were simulated for ...

AIMS Absolute quantification of myocardial blood flow (MBF) with (15)O-water cardiac positron emission tomography (PET)/CT has recently demonstrated to hold promising diagnostic value for the detection of coronary artery disease (CAD). However, methodological differences in utilized analysis software packages (SP) could affect generated MBF values, potentially prohibiting widespread clinical ap...

Methods Forty patients with normal coronaries/minimal stenosis on coronary CT angiography had also undergone vasodilator stress MR (regadenoson n=20, dipyridamole n=20). Seventeen healthy normal volunteers with Framingham score less than 1% underwent vasodilator stress testing with regadenoson and dipyridamole in two separate studies using a SSFP sequence. Stress imaging was done 70 seconds pos...

Chronic Myocardial Hiberation The study of Vanoverschelde et al' demonstrated significant abnormalities on morphological analysis of myocardial biopsies from patients with chronic myocardial hibernation. These morphological changes are very similar to those described previously2 and do not occur in stunning; thus, the investigators correctly state that their patients with left ventricular dysfu...

BACKGROUND Paraoxonase 1 [PON1] is recognized as a protective enzyme against LDL oxidation, and PON1 polymorphism has been described as a factor influencing coronary heart disease [CHD] free survival. As coronary vasoreactivity is a surrogate of future cardiovascular events, we aimed at assessing the respective effect of the PON1 genotype and activity on coronary vasoreactivity in a population ...

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Swiss Science Foundation (SNSF). Background Whether myocardial inflammation causes long-term sequelae potentially affecting blood flow (MBF) is unknown. Objectives To assess the effect on quantitative MBF parameters, as assessed by 13N-ammonia positron emission tomography perfusion...