Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted nanoemulsion) are available. Versatile small-molecule drug(s) targeting multiple pathways of Alzheimer’s disease pathogenesis are known. By incorporating such...

Laser capture microdissection (LCM) allows the isolation of specific cells from thin tissue sections with high spatial resolution. Effective LCM requires precise identification of cells subpopulations from a heterogeneous tissue. Identification of cells of interest for LCM is usually based on morphological criteria or on fluorescent protein reporters. The combination of LCM and rapid immunolabe...

AIMS Cancer cachexia is a syndrome which results in severe loss of muscle mass and marked fatigue. Conditioned media from cachexia-inducing cancer cells triggers metabolic dysfunction in skeletal muscle, including decreased mitochondrial respiration, which may contribute to fatigue. We hypothesized that Lewis lung carcinoma conditioned medium (LCM) would impair the mitochondrial electron transp...

The manufacturing rate of laser chemical machining (LCM) is currently restricted to avoid disruptive boiling bubbles in the process fluid. An increase necessitates adjustments beam or fluid properties. However, current understanding surface removal mechanisms insufficient achieve a consistent quality under these conditions. For an improved modeling, in-process measurements geometry, temperature...

In this paper we perform a further investigation for r-gcd-sum and r-lcm-sum functions. By making use of the properties generalization Euler’s φ-function, Abel’s identity elementary arguments, derive asymptotic formulas average function, function their generalizations. Moreover, also study sums reciprocals r-gcd r-lcm.

Lost circulation refers to loss of part or whole drilling fluid into the formation while operataion. It wastes costly mud and time spent on rig operations. In this study, investigation a natural plant called, Prosopis Farcta (PF), has been done show its effectiveness as lost control material. A series experimental tests have conducted in order discover PF an LCM. Moreover, different particle si...