Over the last decade, a wealth of research has examined the potential benefits of product recommendation agents (PRAs) for improving outcomes for e-commerce consumers and vendors. To date, however, this research has largely overlooked the fundamentally social nature of shopping. In particular, people often shop collaboratively (together) and for hedonic reasons (for enjoyment), but researchers ...

Plasma renin activity (PRA) may be high among teenage and young adult insulin-dependent diabetic subjects. Supine PRA and stimulated PRA were therefore measured in 50 female and 50 male diabetic subjects, 13-20 years old, diagnosed before the age of 16. Fifty percent have been restudied after 4.6 +/- 0.2 (mean +/- SEM) years. Initially, 43% had high PRA (supine 4.0 +/- 0.37, stimulated 12.02 +/...

BACKGROUND We sought to evaluate plasma renin activity (PRA) levels and risk of mortality and cardiovascular events among individuals with elevated blood pressure [systolic blood pressure (SBP) ≥ 140 mmHg] and those with controlled blood pressure (SBP < 140 mmHg) in a large diverse population. METHODS A retrospective cohort study between January 1, 2007, and December 31, 2013, among adults (≥...

BACKGROUND Renin-angiotensin-aldosterone system (RAAS) activation in heart failure with reduced ejection fraction (HFREF) is detrimental through promotion of ventricular remodeling and salt and water retention. AIMS The aims of this article are to describe RAAS activity in distinct HFREF populations and to assess its prognostic impact. METHODS Venous blood samples were prospectively obtaine...

1, 25-Dihydroxycholechalciferol (calcitriol) and 19-nor-1, 25-dihydroxyvitamin D2 (paricalcitol) are vitamin D receptor (VDR) agonists. Previous data suggest VDR agonists may actually increase renin-angiotensin activity, and this has always been assumed to be mediated by hypercalcemia. We hypothesized that calcitriol and paricalcitol would increase plasma renin activity (PRA) independently of p...

Predicted range aggregate (PRA) query is an important researching issue in spatio-temporal databases. Recent studies have developed two major classes of PRA query methods: (1) accurate approaches, which search the common moving objects indexes to obtain an accurate result; and (2) estimate methods, which utilize approximate techniques to estimate the result with an acceptable error. In this pap...

Atchison DK, Harding P, Beierwaltes WH. Vitamin D increases plasma renin activity independently of plasma Ca via hypovolemia and -adrenergic activity. Am J Physiol Renal Physiol 305: F1109 –F1117, 2013. First published August 7, 2013; doi:10.1152/ajprenal.00010.2013.—1, 25-Dihydroxycholechalciferol (calcitriol) and 19-nor-1, 25-dihydroxyvitamin D2 (paricalcitol) are vitamin D receptor (VDR) ago...

The most important goal of this study is to enhance our understanding of the crucial functional relationships that determine the behavior of the systemic circulation and its underlying physiological regulatory mechanisms with minimal modeling. To the present day, much has been said about the indirect hydraulic effects of right atrial pressure (PRA) via cardiac output (CO) on arterial pressure (...

Plasma renin activity (PRA), aldosterone (aldo) levels, electrolyte levels, and blood pressures were measured in 16 patients with affective disorders taking lithium prophylactically, and in 16 age and sex-matched control subjects. PRA and aldo levels were significantly elevated in the lithium-treated group. There was no difference between the groups in plasma electrolytes or erect and supine bl...

In this study the behavioral effects of sectioning the saphenous nerve at the time of application of the loose ligature and the effect of a selective ?1-adrenergic antagonist for two weeks after tying ligatures was examined. Male Sprague-Dawley rats were used in this study. Animals were divided into six groups: Sham-operated, sciatic nerve ligation (CCI), saphenous nerve section (Saph), CCI + S...