A mixed effect model describing median overall survival (mOS) in patients with advanced hepatocellular carcinoma (aHCC) treated with antiangiogenic therapy (AAT) was developed from literature data. Data were extracted from 59 studies, representing 4,813 patients. The final model included estimates of mOS after AAT (8.5 months) or placebo (7.1 months) administration. The mOS increased 21% when t...

BACKGROUND Sensory over-responsivity (SOR) affects many individuals with autism spectrum disorders (ASD), often leading to stressful encounters during daily routines. METHODS This study describes the associations between early SOR symptoms and the longitudinal course of restrictions in family life activities and parenting stress across three time-points in families raising a child with ASD (n...

Superoxide reductases (SORs) are nonheme iron-containing enzymes that reduce HO(2) to H(2)O(2). Exogenous substrates such as N(3)(-) and CN(-) have been shown to bind to the catalytic iron site of SOR, and cyanide acts as an inhibitor. To understand how these exogenous ligands alter the physical and reactivity properties of the SOR iron site, acetate-, azide-, and cyanide-ligated synthetic mode...

OBJECTIVE The aim of this study was to report and compare the anatomic and functional results of primary vitrectomy with and without 360° encircling scleral buckle (SB) for the treatment of rhegmatogenous retinal detachment (RRD) due to inferior retinal break(s). BACKGROUND A variety of options, including SB, pars plana vitrectomy (PPV) with or without SB, and pneumatic retinopexy have been d...

As the development of the PSOR method (a point parallel SOR method by mesh domain partitioning proposed in [SIAM J. Sci. Comput., 20 (1999), pp. 2261–2281], this paper introduces a new mesh domain partition and ordering (the multitype partition and ordering), and proposes a new block parallel SOR (BPSOR) method for numerically solving 2-dimensional (2D) or three-dimensional (3D) elliptic bounda...

PURPOSE: The aim of this study was to investigate the relationship among physiological factors, age, sensory over-responsivity (SOR) and food selectivity in children with autism spectrum disorders (ASD). METHODS: One hundred forty-one parents of children with ASD were recruited through a national autism organization, Autism Speaks, to fill out a survey regarding their child’s mealtime behavior....

In this paper we study a parallel form of the SOR method for the numerical solution of the Convection Diffusion equation suitable for GPUs using CUDA. To exploit the parallelism offered by GPUs we consider the fine grain parallelism model. This is achieved by considering the local relaxation version of SOR. More specifically, we use SOR with red black ordering with two sets of parameters ωi j a...

A straightforward synthetic approach was adopted for the construction of a lysosome-targeted drug delivery system (TDDS) using sorbitol scaffold (Sor) linked to octa-guanidine and tetrapeptide GLPG, a peptide substrate of lysosomal cysteine protease, cathepsin B. The main objective was to efficiently deliver the potential anticancer drug, doxorubicin to the target sites, thereby minimizing dose...

BACKGROUND Apoptosis and matrix metalloproteinase (MMP-9) are capable of hydrolysing components of the extracellular matrix and weakening the fetal membranes which leads to eventual rupture, a key process of human parturition. The aim of this study was to determine the effect of supracervical apposition and spontaneous labour on apoptosis and MMP-9 in human fetal membranes at term. METHODS Fe...

CONTEXT Benefits of breastfeeding include lower risk of postneonatal mortality. However, it is unclear whether breastfeeding specifically lowers sudden infant death syndrome (SIDS) risk, because study results have been conflicting. OBJECTIVE To perform a meta-analysis to measure the association between breastfeeding and SIDS. METHODS We identified 288 studies with data on breastfeeding and ...