BACKGROUND AND PURPOSE Phosphorylation of δ opioid receptors (DOP receptors) by cyclin-dependent kinase 5 (CDK5) was shown to regulate the trafficking of this receptor. Therefore, we aimed to determine the role of CDK5 in regulating DOP receptors in rats treated with morphine or with complete Freund's adjuvant (CFA). As μ (MOP) and DOP receptors are known to be co-regulated, we also sought to d...

Corresponding author: Jie Ae Kim, M.D., Department of Anesthesiology and Pain Medicine, Samsung Medical Center, 50, Ilwon-dong, Gangnam-gu, Seoul 135-710, Korea. Tel: 82-2-3410-0363, Fax: 82-2-3410-6626, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3...

BACKGROUND A broad range of gemcitabine dosages have been used in dogs. HYPOTHESIS/OBJECTIVES To determine maximally tolerated dose (MTD), dose-limiting toxicity (DLT), and preliminary antitumor activity of intravenous administration of gemcitabine in dogs with advanced solid tumors. ANIMALS Twenty-two client-owned dogs. METHODS Dogs with advanced cancer were prospectively enrolled in an ...

Support schemes like the Feed-in-Tariff (FiT) have for many years been an important driver deployment of distributed energy resources, and transition from consumerism to prosumerism. This democratization decarbonization system has led both challenges opportunities operators, paving way emerging concepts local markets. The FiT approach often assumed as lower economic bound a prosumer’s willingne...

Supply chains (SC) present performance bottlenecks that contribute to a high level of costs, infiltration product quality, and impact productivity. Examples such inhibitors include the bullwhip effect, new lines, inventory, restrictive data flows. These can force manufacturers source more raw materials increase production significantly. Also, flow in complex global SC network generally slows do...

BACKGROUND Accelerated hypofractionated radiotherapy can shorten total treatment time and overcome the accelerated repopulation of tumour cells during radiotherapy. This therapeutic approach has demonstrated good efficacy in the treatment of locally advanced non-small-cell lung cancer (NSCLC). However, the optimal fractionation scheme remains uncertain. The purpose of this phase I trial was to ...

Introduction: The 2001 Mars Odyssey GammaRay Spectrometer (GRS) [1] has been a very useful instrument for estimating the amount of sub-surface ice in the polar regions. In our first preliminary look at ice content in these regions [2], we modeled the surface with two layers: a dry layer containing no ice over an ice-rich layer with a variable ice content. We used a plot of the fluxes of epither...

Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II dose (RP2D), and dose-limiting toxicities (DLTs) of combined mTOR inhibitor sirolimus (1 mg-5 mg PO daily) and HDAC inhibitor vorinostat (100 mg...

A c-Met inhibitor tivantinib is a candidate anticancer agent for patients with hepatocellular carcinoma (HCC), and CYP2C19 is the key metabolic enzyme for tivantinib. Previous Japanese phase I studies in patients with solid tumors (except HCC) recommend 360 mg twice daily (BID) and 240 mg BID for CYP2C19 extensive metabolizers (EM) and poor metabolizers (PM), respectively. In this study, Japane...