The ratio of second to fourth digit length (2D:4D) is a correlate of prenatal testosterone. High 2D:4D is associated with low prenatal testosterone, and reduced sensitivity to testosterone. Klinefelter's syndrome (KS; 47 XXY) affects the endocrine system, such that low testosterone levels are found in KS foetuses, new-borns and adults. To date, there are no published data regarding the pattern ...

BACKGROUND Acquired immune deficiency syndrome related Kaposi's sarcoma (AIDS-KS) remains a significant cause of morbidity and mortality. We describe for the first time a proportion of patients with AIDS-KS who presented with no evidence of cutaneous disease. PATIENTS AND METHODS From our cohort of 5932 individuals infected with the human immunodeficiency virus (HIV-1) treated in the HAART er...

AIDS-associated Kaposi's sarcoma (KS) is the most common AIDS-related malignancy in sub-Saharan Africa, with a generally unfavourable prognosis. We report on six-month and 12-month cohort treatment outcomes of human immunodeficiency virus (HIV)-positive KS patients and HIV-positive non-KS patients treated with antiretroviral therapy (ART) in public sector facilities in Malawi. Data were collect...

Klinefelter syndrome (KS) is the most common chromosomal aberration in men. There are approximately 250,000 men with KS in the United States, and the prevalence of KS in male reproductive practices is 3 to 4%; however, most men are never diagnosed. KS has an effect on normal development, growth, social interactions, bone structure, and sexual and reproductive function, thus a multidisciplinary ...

Introduction: Kaposi’s sarcoma (KS) is an angioproliferative disorder first described in 1872 by Moritz Kaposi. Four main clinical presentations of KS have been described: classic, endemic, iatrogenic and epidemic. KS involvement of the lymph nodes is extremely uncommon in the classical variant form, especially if it precedes the skin manifestations. We describe the case of an elderly HIV-negat...

The life expectancy for HIV-positive individuals has improved over time due to increasing access to highly active antiretroviral therapy (HAART). Yet, as the HIV-positive population ages, their risk of developing cancers also increases. Studies of Kaposi's sarcoma (KS) among elderly HIV-infected persons are quite limited. We examined the age patterns of KS incidence and an association between a...

Our arsenals for fighting off bacteria are so powerful, and involve so many different defense mechanisms, that we are in more danger from them than the invaders. We live in the midst of explosive devices; we are mined. --Lewis Thomas, MD The Lives of a Cell Although the late Dr. Thomas was actually referring to bacterial sepsis, his statement could easily have applied to the cytokine "storm" of...

J. Kim, I-Y. Choi, M. L. Michaelis, and S-P. Lee Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, Neurology, University of Kansas Medical Center, Kansas City, KS, United States, Pharmacology & Toxicology, University of Kansas, Lawrence, KS, United States, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, U...

BACKGROUND Involvement of the subcutis by Kaposi sarcoma (KS) occurs primarily when cutaneous KS lesions evolve into deep penetrating nodular tumors. Primary KS of the subcutaneous tissue is an exceptional manifestation of this low-grade vascular neoplasm. CASE PRESENTATION We present a unique case of acquired immune deficiency syndrome (AIDS)-associated KS manifesting primarily in the subcut...

One of the most significant current discussions in Knowledge Sharing (KS) is security. Security is an important component in KS, and plays a key role in reducing the risks in KS. However, relatively little study has been performed on KS security in the public and private sectors, and even less in the developing countries. This research intends to find the relationship between organizational con...