Action potential (AP) responses of dentate gyrus granule (DG) cells have to be tightly regulated to maintain hippocampal function. However, which ion channels control the response delay of DG cells is not known. In some neuron types, spike latency is influenced by a dendrotoxin (DTX)-sensitive delay current (ID) mediated by unidentified combinations of voltage-gated K(+) (Kv) channels of the Kv...

This study investigated the regulation of glucose uptake in Atlantic cod (Gadus morhua) hearts. Isolated hearts were perfused with or without glucose in the medium, under either normoxic or severely hypoxic conditions. Working at basal levels, hearts did not require extracellular glucose to maintain power under aerobic conditions. However, cardiac performance was significantly reduced without e...

For a graph G = (V,E), the modified Schultz index of G is defined as S∗(G) = ∑ {u,v}⊆V (G) (dG(u) · dG(v))dG(u, v) where dG(u) (or d(u)) is the degree of the vertex u of G, and dG(u, v) is the distance between u and v. Let B(n) be the set of bicyclic graph with n vertices. In this paper, we study the modified Schultz index of B(n), graphs in B(n) with the smallest modified Schultz index S∗(G) a...

Double-Gate (DG) MOSFET has emerged as one of the most promising devices for logic and memory circuit design in sub 10nm regime. In this paper, we investigate the gate-to-channel leakage, EDT, BTBT and sub-threshold leakage for DG MOSFET. Simulations are performed using 2D Poisson-Schrödinger simulator with tight-binding Green’s function approach. Then we analyze the effect of parameter variati...

Distributed generation (DG) sources are becoming more prominent in distribution systems due to the incremental demands for electrical energy. Locations and capacities of DG sources have great impacts on the system losses in a distribution network. This paper presents a study aimed for optimally determining the size and location of distributed generation units in distribution systems with differ...

Aryl hydrocarbons such as 3-nitrobenzanthrone (NBA), 4-aminobiphenyl (ABP), acetylaminofluorene (AAF), benzo(a)pyrene (BaP), and 1-nitropyrene (NP) form bulky DNA adducts when absorbed by mammalian cells. These chemicals are metabolically activated to reactive forms in mammalian cells and preferentially get attached covalently to the N2 or C8 positions of guanine or the N6 position of adenine. ...

Phenotypes of the tomato (Solanum lycopersicum) high pigment-2(dg) (hp-2(dg)) and hp-2(j) mutants are caused by lesions in the gene encoding DEETIOLATED1, a negative regulator of light signaling. Homozygous hp-2(dg) and hp-2(j) plants display a plethora of distinctive developmental and metabolic phenotypes in comparison to their normal isogenic counterparts. These mutants are, however, best kno...

We have here examined chemopotentiating effects of glycolysis inhibitor 2-deoxy-d-glucose (DG) in two epithelial ovarian carcinoma (EOC) cell lines and 17 freshly isolated ascitic EOC cell samples, and we identify low expression of the beta-F1-ATPase involved in mitochondrial ATP production as a candidate marker for sensitivity to this strategy. Although in the majority of samples, DG per se di...

beta-Dystroglycan (beta-DG) is a dystrophin-associated glycoprotein that is expressed in skeletal muscle and other tissues. In the retina, dystrophin is present in the outer plexiform layer (OPL), where it is enriched under the photoreceptor cell membrane. In this study we determined the immunocytochemical localization of beta-DG at both light and electron microscopic levels. beta-DG immunoreac...