Hematopoietic stem cells (HSCs) maintain the turnover of mature blood cells during steady state and in response to systemic perturbations such as infections. Their function critically depends on complex signal exchanges with the bone marrow (BM) microenvironment in which they reside, but the cellular mechanisms involved in HSC-niche interactions and regulating HSC function in vivo remain elusiv...

The hematopoietic stem cell (HSC) niche provides essential microenvironmental cues for the production and maintenance of HSCs within the bone marrow. During inflammation, hematopoietic dynamics are perturbed, but it is not known whether changes to the HSC-niche interaction occur as a result. We visualize HSCs directly in vivo, enabling detailed analysis of the 3D niche dynamics and migration pa...

The hematopoietic stem cell (HSC) niche commonly refers to the pairing of hematopoietic and mesenchymal cell populations that regulate HSC self-renewal, differentiation, and proliferation. Anatomic localization of the niche is a dynamic unit from the developmental stage that allows proliferating HSCs to expand before they reach the bone marrow where they adopt a quiescent phenotype that protect...

Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanisms underlying this variability in HSC division kinetics are unknown. We report here that quiescence exit kinetics are differentially regulated...

1Tumor Immunology Program, Stanley S. Scott Cancer Center, Louisiana State University–Health Sciences Center (LSU-HSC), New Orleans; 2Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA; 3Department of Pediatrics, LSU-HSC, New Orleans; 4School of Public Health, Louisiana State University, New Orleans; 5Ochsner Clinic Foundation, New Orleans, LA; and 6Dep...

45 46 The myofibroblastic differentiation of hepatic stellate cells (HSC) is a critical event in liver 47 fibrosis and is part of the final common pathway to cirrhosis in chronic liver disease from 48 all causes. The molecular mechanisms driving HSC differentiation are not fully 49 understood. Because macroscopic tissue stiffening is a feature of fibrotic disease, we 50 hypothesized that mechan...

Abstract By using the subregion CV conjecture, we numerically investigate behavior of holographic complexity (HSC) and compare it with entanglement entropy (HEE) in unbalanced superconductors, which indicates that both HEE HSC can be used as good probes to phase transition superconductors. We observe exhibit a similar linear growth change width for strip geometry. However, different fixed width...

This study introduces, two models based on Gene Expression Programming (GEP) to predict compressive strength of high strength concrete (HSC). Composition of HSC was assumed simplified, as a mixture of six components (cement, silica fume, super-plastisizer, water, fine aggregate and coarse aggregate). The 28-day compressive strength value was considered the target of the prediction.  Data on 159...

Despite the numerous advantages of using concrete with high strength capacity, the brittle behavior of high strength concrete (HSC) and higher production cost has limited its use in the construction industry. This research aims to develop a cost-effective approach for production of high strength self-compacting concrete with desirable performance in either compressive or tensile loading conditi...

The tumor microenvironment contains unique immune cells, termed myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs) that suppress host anti-tumor immunity and promote tumor angiogenesis and metastasis. Although these cells are considered a key target of cancer immune therapy, in vivo animal models allowing differentiation of human immunosuppressive myeloid cells ha...