Thirty-six Salmonella enterica serovar Typhi-specific genes, absent from the Salmonella enterica serovar Typhimurium genome, that were expressed in human macrophages were identified by selective capture of transcribed sequences. These genes are located on 15 unique loci of the serovar Typhi genome, including Salmonella pathogenicity islands (SPI-7, SPI-8, and SPI-10) and bacteriophages (ST15, S...

Retinoic acid receptors (RAR) belong to the same nuclear receptor superfamily as thyroid hormone receptors (TR) that were previously shown to be modulated by dietary soy protein isolate (SPI). This study has examined the effect of dietary SPI and isoflavones (ISF) on hepatic RAR gene expression and DNA binding activity. In Expt. 1, Sprague-Dawley rats were fed diets containing 20% casein or 20%...

Software development is in constant change. New software development strategies, methods, processes, and tools are constantly introduced and taken in use. Simultaneously, the growth and importance of software has accelerated, and software has become a fundamental part of a whole range of different products. Software development strategies are changing as well: globally distributed software deve...

The multistage process of cancer formation is driven by the progressive acquisition of somatic mutations. Replication stress creates genomic instability in mammals. Using a well-defined multistep leukemia model driven by Spi-1/PU.1 overexpression in the mouse and Spi-1/PU.1-overexpressing human leukemic cells, we investigated the relationship between DNA replication and cancer progression. Here...

Software Process Improvement (SPI) is an approach to systematic and continuous improvement of a software development organisation’s ability to develop quality software. SPI requires improvement trough learning and knowledge creation around software development processes. Knowledge management (KM) is therefore an important component of a successful SPI effort. Many SPI programs are often based o...

Quite a lot of attention has been paid in the literature on “how to adopt” software process improvement (SPI) in Small and Medium Size (SME) software organization in several countries. This has resulted in limited improvements to the software industry and impacted the Saudi’s economy. However, the SPI adoption is one of the major issues in the domain of small and medium size software organizati...

This study was to develop novel soy protein isolate-based films for packaging using halloysite nanotubes (HNTs), poly-vinyl alcohol (PVA), and 1,2,3-propanetriol-diglycidyl-ether (PTGE). The structural, crystallinity, opacity, micromorphology, and thermal stability of the resultant SPI/HNTs/PVA/PTGE film were analyzed by the Attenuated total reflectance-Fourier transformed infrared (ATR-FTIR) s...

Fifty-eight men at high risk of prostate cancer or with low-grade prostate cancer were randomly assigned to consume 1 of 3 protein isolates containing 40 g protein: 1) soy protein (SPI+, 107 mg isoflavones/d); 2) alcohol-washed soy protein (SPI-, <6 mg isoflavones/d); or 3) milk protein (MPI). Proliferating cell nuclear antigen (PCNA), epidermal growth factor receptor, B-cell non-Hodgkin lympho...

Induction of invasion gene transcription and expression of the invasive phenotype of Salmonella strains are regulated by environmental conditions. Experimental evidence indicates that oxygen, pH, and osmotic conditions need to closely resemble those of the host intestinal lumen for invasion gene activation. The hilA gene, encoded on Salmonella pathogenicity island 1 (SPI-1), is a transcriptiona...

Prediction of drought and flood events can be difficult, but the standardized precipitation index (SPI) calculated from monthly data may be a useful tool for predicting future dryness/wetness events in China. The rainy season SPI was calculated from monthly precipitation data from 3804 meteorological stations in China. The spatiotemporal variation, periodic change, and trend in rainy season SPI...