We determined whether the extrinsically denervated heart becomes supersensitive to acetylcholine (ACh) and nicotine (NIC). Fifteen mongrel dogs were subjected to total extrinsic cardiac denervation. The negative inotropic responses of their hearts were compared with those of 15 control dogs with respect to ACh (0.005-1.0 pig) and NIC (10-300 fig) administered intracoronary. All dogs were placed...

The paper describes the synthesis of pH sensitive interpenetrating polymeric network (IPN) beads composed of chitosan, glycine, glutamic acid, cross linked with glutaraldehyde and their use for controlled drug release. The drug was loaded into beads by varying their composition such as, amount of crosslinker glutaraldehyde, ratio of chitosan, glycine and glutamic acid. The beads were characteri...

AIMS The purpose of this study was to investigate the reinforcement effect of short E-glass fiber fillers on some mechanical properties of temporary crown and bridge (TCB) composite resin with a semi-interpenetrating polymer network (semi-IPN). METHODS AND MATERIALS Experimental temporary fiber reinforced (TFC) composite resin was prepared by mixing 15 wt% of short E-glass fibers (3 mm in len...

The heart peptide hormone atrial natriuretic peptide (ANP) regulates blood pressure by stimulating guanylyl cyclase-A to produce cyclic guanosine monophosphate (cGMP). ANP and guanylyl cyclase-A are also expressed in many brain areas, but their physiological functions and downstream signaling pathways remain enigmatic. Here we investigated the physiological functions of ANP signaling in the neu...

We determined whether the extrinsically denervated heart becomes supersensitive to acetylcholine (ACh) and nicotine (NIC). Fifteen mongrel dogs were subjected to total extrinsic cardiac denervation. The negative inotropic responses of their hearts were compared with those of 15 control dogs with respect to ACh (0.005-1.0 pig) and NIC (10-300 fig) administered intracoronary. All dogs were placed...