Methods: Two NSCLC cell lines (HCC827 and HCC4006) with EGFR mutations (exon 19 deletions) were selected. MTT and annexin-V binding assays were performed to determine cell proliferation and apoptotic cell death upon TKI treatment respectively. Autophagy was determined by conversion of LC3I to LC3II, formation of ATG5/12 conjugation and p62 degradation using Western blot. Acidic vesicular organe...

Abstract The frequency-dependent amplitude-versus-offset (FAVO) method has become a practical for fluid detection in sand reservoirs. At present, most FAVO inversions are based on the assumption that reservoirs isotropy, but application effect is not satisfactory fractured Hence, we analyse frequency variation characteristics of anisotropy parameters tight sandstone new petrophysical model, and...

We are developing a large-scale model of language comprehension in ACT-R 6 for use in the creation of a synthetic teammate that can function as the Air Vehicle Operator (AVO) in a three-person simulation of an Unmanned Aerial Vehicle (UAV) team performing a reconnaissance mission. The use of ACT-R 6 to implement the core components of this system reflects the strong cognitive modeling orientati...