simply stated, a vaR model is a model of the distribution of future profits and losses of a bank’s trading portfolio. vaR models combine information on a bank’s trading positions across various products with statistical estimations of the probability distribution of the underlying market factors and their relation to each other. the final output of a vaR model is a vaR estimate, which is define...

Malaria parasites use antigenic variation to avoid immune clearance and increase the duration of infection in the human host. Variation at the surface of P. falciparum-infected erythrocytes is mediated by the differential control of a family of surface antigens encoded by var genes. Switching of var gene expression occurs in situ, mostly from telomere-associated loci, without detectable DNA alt...

Sequence data from four gene regions (nrDNA, petN-psbM, trnD-trnT, trnS-trnG, 3,705 bp) revealed that junipers from the southern mountain ranges of Iran are very diverse. The combined NJ tree (3,705 bp) showed strong support for the distinct nature of J. excelsa, J. polycarpos, J. p. var. turcomanica, and J. p. var. seravschanica. The samples from NW Iran are J. polycarpos and samples from NE I...

Recognizing the drawbacks of Value-at-Risk (VaR), researchers have advocated the use of Conditional Value-at-Risk (CVaR). However, the current popularity of VaR and Stress Testing (ST) among bank regulators raises the question of whether a risk management system based on both VaR and ST constraints is an effective alternative to a system based on CVaR. We show that when the VaR and ST bounds ar...

Antigenic variation in Plasmodium falciparum is regulated by transcriptional switches among members of the var gene family, each expressed in a mutually exclusive manner and encoding a different variant of the surface antigens collectively named PfEMP1. Antigenic switching starts when the first merozoites egress from the liver and begin their asexual proliferation within red blood cells. By era...

We propose a mixed-effects vector auto-regressive (ME-VAR) model for studying brain effective connectivity. One common approach to investigating inter-regional associations in brain activity is the multivariate auto-regressive (VAR) model. The standard VAR model unrealistically assumes the connectivity structure to be identical across all participants in a study and therefore, could yield misle...

Benzoxazolin-2(3H)-one (BOA) is a well known allelochemical that is being explored for its herbicidal activity. However, not much is known about its effect on crop plants. The present study investigated the effect of BOA on germination and early growth of four vegetable crops viz. Pisum sativum L., Raphanus sativus L., Brassica oleracea L. var. botrytis and Brassica oleracea L. var. capitata. A...

Smoking Cessation Treatment (SCT) is a policy that has to be promoted for health economics, and expectations for the success of treatments with varenicline (VAR) are large. However, the Food and Drug Administration (FDA) have issued a warning on VAR-induced depression and suicide. In the present study, utilizing the FDA Adverse Event Reporting System (FAERS), we searched for antidepressants (AD...