CONTEXT Insulin resistance is associated with altered vascular function in diabetes. OBJECTIVE The objective of the study was to define the overall and regional aortic function as well as the changes of aortic function over time in nondiabetic individuals with insulin resistance and a normal oral glucose tolerance test (OGTT). DESIGN This was a cross-sectional and longitudinal analysis with...

Information systems infrastructure (ISI) was ranked as the most important issue in a 1994-1995 study of key issues in IS management (Brancheau et al. 1996). Yet, to date, little theoretical and empirical work has been done in this area. This study attempts to reconceptualize the ISI construct and its measures. Drawing from the literature, this study envisions ISI as a base of shared technologic...

We investigate the energy efficiency of interspike interval (ISI) neural codes. Using the hypothesis that nature maximizes the energy efficiency of information processing, it is possible to derive neuronal firing frequencies which maximize the information/energy ratio. With simple assumptions about the encoded ISI and noise distributions, we show that ISI codes can be at least as efficient as d...

Sequences of first-passage times can describe the interspike intervals (ISI) between subsequent action potentials of sensory neurons. Here, we consider the ISI statistics of a stochastic neuron model, a leaky integrate-and-fire neuron, which is driven by a strong mean input current, white Gaussian current noise, and a spike-frequency adaptation current. In previous studies, it has been shown th...

BACKGROUND This study sought to map the Insomnia Severity Index (ISI) and symptom variables onto the EQ-5D. METHODS A cross-sectional survey was conducted among adult US residents with self-reported sleep problems. Respondents provided demographic, comorbidity, and sleep-related information and had completed the ISI and the EQ-5D profile. Respondents were classified into ISI categories indica...

We have previously shown that event-related functional magnetic resonance imaging (ER-fMRI) may be used to record responses to the rapid, interleaved presentation of stimuli in the three-stimulus oddball task. The present study examined the sensitivity of ER-fMRI responses to variations in the range of inter-stimulus intervals (ISIs, calculated as the time from the offset of one stimulus to the...