نتایج جستجو برای: پلیمر plga

تعداد نتایج: 7972  

2017
Meng Wu Ying Wang Yiru Wang Mingbo Zhang Yukun Luo Jie Tang Zhigang Wang Dong Wang Lan Hao Zhibiao Wang

In the current study, we synthesized prostate cancer-targeting poly(lactide-co-glycolic acid) (PLGA) nanobubbles (NBs) modified using A10-3.2 aptamers targeted to prostate-specific membrane antigen (PSMA) and encapsulated paclitaxel (PTX). We also investigated their impact on ultrasound (US) imaging and therapy of prostate cancer. PTX-A10-3.2-PLGA NBs were developed using water-in-oil-in-water ...

2012
Rajesh Vasita Dhirendra S Katti

BACKGROUND Hydrophobic biopolymers such as polylactide-co-glycolide (PLGA, 85:15) have been extensively explored as scaffolding materials for tissue engineering applications. More recently, electrospun microfiber-based and nanofiber-based scaffolds of PLGA have received increased attention because they act as physical mimics of the fibrillar extracellular matrix. However, the hydrophobicity of ...

2017
Laura Fernández-Sánchez Irene Bravo-Osuna Pedro Lax Alicia Arranz-Romera Victoria Maneu Sergio Esteban-Pérez Isabel Pinilla María Del Mar Puebla-González Rocío Herrero-Vanrell Nicolás Cuenca

Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site of action. The purpose of this work was to assess the efficacy of intravitreal controlled delivery of tauroursodeoxycholic acid (TUDCA) encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres for the treatment of the retina in a rat ...

Journal: :Journal of biomedical materials research. Part A 2008
Dennis P Link Juliette van den Dolder Jeroen J J P van den Beucken Vincent M Cuijpers Joop G C Wolke Antonios G Mikos John A Jansen

In this study, the biocompatibility of a calcium phosphate (CaP) cement incorporating poly (D,L-lactic-co-glycolic acid) (PLGA) microparticles was evaluated in a subcutaneous implantation model in rats. Short-term biocompatibility was assessed using pure CaP discs and CaP discs incorporating PLGA microparticles (20% w/w) with and without preincubation in water. Long-term biocompatibility was as...

2015
F. Ahmadi K. Derakhshandeh A. Jalalizadeh A. Mostafaie L. Hosseinzadeh

Ovarian cancer is the fifth leading cause of the cancer-related death among women. 9-nitrocamptothecin (9-NC) is a water-insoluble derivative of camptothecin used for the treatment of patients with advanced ovarian cancer. Previous studies showed that the encapsulation of 9-NC in poly (lactic-co-glycolic acid, PLGA) nanoparticles increased the cytotoxic effect of the drug on different cancer ce...

Journal: :journal of research in medical sciences 0
saeid abrishamkar professor, department of neurosurgery, school of medicine, isfahan university of medical sciences, isfahan, iran mostafa torkashvand resident, department of neurosurgery, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran arash momeni borujeni student of master, school of biomaterial (drug delivery system), amirkabir university of technology, tehran, iran amir momani borujeni general practitioner, school of medicine, isfahan university of medical sciences, isfahan, iran majid rezvani assistant professor, department of neurosurgery, school of medicine, isfahan university of medical sciences, isfahan, iran homayon tabesh assistant professor, department of neurosurgery, school of medicine, isfahan university of medical sciences, isfahan, iran

normal 0 false false false en-us x-none ar-sa backgrounds : lumbar disc herniation (ldh) is the most common surgical intervention of spine surgery. during few days of the operation, most patients experience worrying low back pain ( lbp) and radicular leg pain (rlp). applying liquid form of bupivacaine in the vicinity of surgical field could be effective on pain relief only for few hours after o...

Journal: :Ear, nose, & throat journal 2005
Daniel D Charous Mary F Cunnane Marc R Rosen William M Keane

Polymorphous low-grade adenocarcinoma (PLGA) is a malignant neoplasm that tends to follow a benign clinical course. Recurrences are uncommon. We report a case of recurrent PLGA of the paranasal sinuses that manifested as a large mass that filled the entire nasal cavity and left maxillary sinus. To our knowledge, this is the first reported case of a recurrent PLGA of the paranasal sinuses.

Journal: :Biomaterials 2007
Xuejun Xin Mohammad Hussain Jeremy J Mao

Nanofibers have recently gained substantial interest for potential applications in tissue engineering. The objective of this study was to determine whether electrospun nanofibers accommodate the viability, growth, and differentiation of human mesenchymal stem cells (hMSCs) as well as their osteogenic (hMSC-Ob) and chondrogenic (hMSC-Ch) derivatives. Poly(d,l-lactide-co-glycolide) (PLGA) beads w...

2015
Taiki Miyazawa Kiyotaka Nakagawa Takahiro Harigae Ryo Onuma Fumiko Kimura Tomoyuki Fujii Teruo Miyazawa

PURPOSE Biodegradable nanoparticles (NPs) composed of poly(D, L-lactide-co-glycolide) (PLGA) have attracted considerable attention as delivery systems of drugs and antioxidative compounds, such as β-carotene (BC). Intravenous (IV) administration of BC-containing PLGA-NPs (BC-PLGA-NPs) coated with polysorbate 80 (PS80) has been shown to effectively deliver BC to the brain. However, the whole-bod...

2016
Piyachat Roopngam Kewei Liu Lin Mei Yi Zheng Xianbing Zhu Hsiang-I Tsai Laiqiang Huang

Hepatitis C virus (HCV) is known to cause hepatitis and hepatocellular carcinoma. E2 envelope glycoprotein of HCV type (HCV-E2) has been reported to bind human host cells and is a major target for developing anti-HCV vaccines. However, the therapeutic vaccine for infected patients still needs further development. The vaccine aims to provide cytotoxic T-cells to eliminate infected cells and hepa...

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