Standard cytochemical methods were used to investigate the ameliorative effect of melatonin (0.2 mM) on chromosomal aberrations in human lymphocyte cultures induced by arsenic (As2O3, 1.4 μM) and/or fluoride (NaF, 34 μM). As2O3 and/or NaF generated a significant increase in the incidence of chromosomal aberrations as compared to control levels. Combined treatment with As2O3 and NaF induced more...

The effect of sodium fluoride (NaF) on the incorporation of [2-14C] thymidine into DNA in germinating mung bean (Vigna radiate cv Uthong-1) seedlings was studied. One-day-old mung bean seedlings were treated with water (control) or 1.0 mM NaF containing [2-14C]thymidine for 24 h and the thymidine incorporation into various parts of the radicle was examined. Silver grains shown by the autoradiog...

This study aimed to explore the effect of fluoridated toothpastes on biofilm architecture and enamel demineralization in an in vitro biofilm model. Streptococcus mutans was grown on enamel and treated with slurries of commercial toothpastes, containing SnF2 or NaF. Water and chlorhexidine were used as negative and positive controls, respectively. The developed biofilms were imaged and enamel de...

Distribution of lactate dehydrogenase (LDH) and succinic dehydrogenase (SDH) in the ovary of mice treated with two chronic doses of sodium fluoride (NaF), for five days, in drinking water. LDH histochemical reactivity was observed following Hess et al., (1958) technique and SDH histochemical reactivity was obtained using the method of Nachlas et al., (1957). A decreasing trend of enzyme reactiv...

Human toxicity NaF and ionic fluoride, later only fluoride (1 mg of NaF corresponds to 0.45 mg of fluoride, also called “fluor”) are toxic for humans at the higher doses; gastrointestinal symptoms have occurred following fluoride ingestion from 3 to 5 mg/kg of body weight. The lethal doses of NaF in adults range from 70 to 140 mg/kg, which corresponds to 31.5-63 mg fluoride/kg of body weight [2...

Extracranial metastases from glioblastoma multiforme (GBM) are rare. We report a case of osseous metastases from GBM diagnosed by F-NaF PET/CT. A 30-year-old man with a history of GBM presented with bone pain and underwent F-NaF PET/CT for further evaluation. On PET/CT, intense uptake in 2 bone lesions was noted. Histopathologic evaluation revealed osseous metastases from GBM. Although rare, bo...

Our aim was to prospectively evaluate the relationship between low back pain-related disability and quantitative measures from [18F]-sodium fluoride ([18F]-NaF) MR imaging. Six patients with facetogenic low back pain underwent dynamic [18F]-NaF PET/MR imaging. PET metrics were correlated with clinical measures and MR imaging grading of lumbar facet arthropathy. A significant positive correlatio...

The traditional presentation of Kowalski's Event Calculus as a logic program uses Negation-as-Failure (NAF) in an essential way to support persistence of uents. In this paper we present an implementation of Event Calculus as a purely logical (without NAF) Linear Logic (LL) program. This work demonstrates some of the internal non-monotonic features of LL and its suitability for knowledge update ...

Objective: Naftopidil (NAF) is a selective alpha1-adrenergic receptor antagonist with nearly 20% bioavailability due to poor aqueous solubility, permeability, and extensive first-pass metabolism. To improve the of NAF, solid lipid nanoparticles (SLN) NAF were prepared. Methods: SLNs prepared using solvent emulsification/evaporation method excipients Compritol 888 ATO Poloxamer 188. Formulation ...

This in vitro study evaluated the preventive potential of experimental pastes containing 10% and 20% hydroxyapatite nanoparticles (Nano-HAP), with or without fluoride, on dental demineralization. Bovine enamel (n=15) and root dentin (n=15) specimens were divided into 9 groups according to their surface hardness: control (without treatment), 20 Nanop paste (20% HAP), 20 Nanop paste plus (20% HAP...