UV radiation induced genomic instability is one of the leading causes for melanoma. Phosphorylation of Ataxia Telangiectasia Mutated (ATM) is one of the initial events that follow DNA damage. Phospho-ATM (p-ATM) plays a key role in the activation of DNA repair and several oncogenic pathways as well as in the maintenance of genomic integrity. The present study was therefore performed to understa...

Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and repair of these breaks by nonhomologous end-joining. Because the protein kinase ataxia telengiectasia (AT) mutated (ATM) plays a critical role in DSB repair and AT patients show abnormalities of Ig isotype expression, we assessed the role of ATM in CSR by examining ATM-d...

T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature leukemia that occurs both in adults as a sporadic disease and in younger patients suffering an hereditary condition, ataxia telangiectasia (AT). The ATM gene, located in the 11q22-23 chromosomal region, is consistently mutated in AT patients. The strong predisposition of AT patients to develop T-PLL and the high frequency of T-cell...

The Advanced Network Technologies is a research that investigates the technology(s) behind today’s modern networks and network infrastructures one of these technologies being Asynchronous Transfer Mode (ATM). Therefore, also focuses its attention on ATM. Dubbed “Modelling and Performance Studies of ATM Networks”; this research seeks to look at, and into, the impact of application segment length...

The Asynchronous Transfer Mode (ATM) networks are quickly being adopted as backbones over various parts of the Internet. This paper analyzes the performance of TCP/IP protocols over ATM network's Available Bit Rate (ABR) and Unspeciied Bit Rate (UBR) services. It is shown that ABR pushes congestion to the edges of the ATM network while UBR leaves it inside the ATM portion.

Since the beginning of 1995, ATM support has been developed for Linux. By now, Linux supports most functionality that is required for state of the art ATM networking. This article introduces to general ATM concepts, presents the current status of development on Linux, and outlines the future direction ATM on Linux will take.

ATM and ATR are well documented for their roles in maintaining the integrity of genomic DNA by responding to DNA damage and preparing the cell for repair. Since ATM and ATR have been reported to exist in complexes with histone deacetylases, we asked whether Atm and Atr might also uphold gene silencing by heterochromatin. We show that the Atm/Atr inhibitor 2-aminopurine causes the inactive X chr...

The ataxia-telangiectasia mutated (ATM) protein is an apical kinase that orchestrates the multifaceted DNA-damage response. Normally, ATM kinase is in an inactive, homodimer form and is transformed into monomers upon activation. Besides a conserved kinase domain at the C terminus, ATM contains three other structural modules, referred to as FAT, FATC and N-terminal helical solenoid. Here we repo...

| The advent of switched LAN and ATM technology is dramatically altering today's networking environment. Given the preponderance of existing Ethernet networks today, high-speed, switched and/or full-duplex Ethernet and Ethernet LAN Em-ulation over ATM are extremely important, as is bridging between Ethernet and ATM. In this paper , we evaluate the performance of these newly emerging technologie...

This paper presents a fuzzy logic based ATM cell scheduling technique for input buuered non-blocking (ATM) switches. Simulation results indicate that such scheduling signiicantly reduces the average wait time for high priority cells when compared with single and multiple priority FIFO buuers. Simulations were run on an actual trace of ATM video cells generated by an ATM camera. These ATM video ...