Abstract BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) provide a better prognosis in EGFR-mutant non-small cell lung cancer (NSCLC). Nevertheless, the outcome of leptomeningeal metastasis (LM) remains poor. In addition, due to limited access intracranial tumour tissue, gene alterations associated with from adenocarcinoma (LM-LUAD) are unclear. METHODS Forty-...