Previous work has shown that deletion of the partition (par) locus of plasmid pSC101 results in decreased overall superhelical density of plasmid DNA and concommitant inability of the plasmid to be stably inherited in populations of dividing cells. We report here that the biological effects of par correlate specifically with its ability to generate supercoils in vivo near the origin of pSC101 D...

PURPOSE The urokinase-type plasminogen activator receptor (u-PAR) contributes to colon cancer invasion and metastases. We have shown previously that u-PAR expression in colon cancer is driven by the Src tyrosine kinase. In the current study, we determined the ability of PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), a Src kinase inhibitor, to reduce u-PAR expression and ...

New ages are computed for the stars from the Edvardsson et al. (1993) data set. The revised values are systematically larger toward older ages (t>4 Gyr), while they are slightly lower for t<4 Gyr. The systematic difference to older age becomes ∼2 Gyr smaller, when the LutzKelker correction is applied. The Lutz-Kelker corrected values are slightly older than the ages computed from the Hipparcos ...

We report new photometry of populous intermediate-age clusters in the SMC using the Hubble Space Telescope. In contrast to the accepted picture, these clusters appear to have formed in two brief intervals, one 8 ± 2 Gyr ago, and a more recent burst 2 ± 0.5 Gyr ago. When the ridgelines of the four clusters (NGC 339, 361, 416, and Kron 3) in the 8 Gyr burst are aligned, the dispersion in turnoff ...

une controverse s&apos;est élevée en droit et pratique judiciaire iranienne sur la question du dessaisissement du juge en cas d&apos;une clause d&apos;arbitrage international. en fait, le problème est résolu lorsqu&apos;il s&apos;agit d&apos;un arbitrage interne par application de l&apos;article 454 du code de procédure civile lequel permet aux parties de soumettre leur différend ne ou a naître...

Recent studies have indicated that activated protein C (APC) may exert its cytoprotective and anti-inflammatory activities through the endothelial protein C receptor (EPCR)-dependent cleavage of protease-activated receptor 1 (PAR-1) on vascular endothelial cells. Noting that (1) the activation of protein C on endothelial cells requires thrombin, (2) relative to APC, thrombin cleaves PAR-1 with ...

Polarity is a fundamental cellular feature that is critical for generating cell diversity and maintaining organ functions during development. In C. elegans, the one-cell embryo is polarized via asymmetric localization of the PAR proteins, which in turn are required to establish the future anterior-posterior axis of the embryo. PAR-3, a conserved PDZ domain-containing protein, acts with PAR-6 an...