The use of whole-genome sequencing in biomedical research is expected to produce dramatic advances in human health. The increasing use of this powerful, data-rich new technology in research, however, will inevitably give rise to incidental findings (IFs)-findings with individual health or reproductive significance that are beyond the aims of the particular research-and the related questions of ...

Reliability, availability and scalability are major concerns in the design of distributed file systems. We have built an island-based file system (IFS) called Archipelago to solve these problems by failure isolation and low-cost consistency maintenance. The building blocks of IFS are smaller self-contained file servers called islands. The main idea underlying island-based design is the one-isla...

We weigh the presumed benefits of routinely searching all research scans for incidental findings (IFs) against its substantial risks, including false-positive and false-negative findings, and the possibility of triggering unnecessary, costly evaluations and perhaps harmful treatments. We argue that routinely searching for IFs may not maximize benefits and minimize risks to participants.

Iterated Function Systems (IFS) raster compression techniques achieve their results by identifying self-similarities in the source image. However, not all source images contain exploitable self-similarity. We describe a compression technique that combines a Karhunen-Loeve basis set (for non self-similar aspects of an image) with a block based IFS.

DNA analysis is increasingly used to identify the remains of victims of conflicts and disasters. This is especially true in cases where remains are badly damaged and fragmented, or where antemortem records are unavailable. Incidental findings (IFs)-that is, genetics-related information for which investigators were not looking-may result from these identification efforts employing DNA analysis. ...

Intermediate filament (IF) proteins upregulation is a hallmark of astrocyte activation and reactive gliosis, but its pathophysiological implications remain incompletely understood. A recently reported association between IFs and directional mobility of peptidergic vesicles allows us to hypothesize that IFs affect vesicle dynamics and exocytosis-mediated astrocyte communication with neighboring ...

Eukaryotic cells contain three cytoskeletal filament systems that exhibit very distinct assembly properties, supramolecular architectures, dynamic behaviour and mechanical properties. Microtubules and microfilaments are relatively stiff polar structures whose assembly is modulated by the state of hydrolysis of the bound nucleotide. In contrast, intermediate filaments (IFs) are more flexible apo...

Moran’s Theorem is one of the milestones in Fractal Geometry. It allows the calculation of the similarity dimension of any (strict) self-similar set lying under the open set condition. Throughout a new fractal dimension we provide in the context of fractal structures, we generalize such a classical result for attractors which are required to satisfy no separation properties.

Valuations | morphisms from (; ; e) to ((0; 1); ; 1) | are a simple generalization of Bernoulli morphisms (distributions, measures) as introduced in 4,6]. Here, we show how to generalize the notion of entropy (of a language) in order to obtain new formulae to determine the Haus-dorr dimension of fractal sets (especially in Euclidean spaces) especially deened via regular !-languages. In this way...